Boron compounds against human leukemic cells |
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| Authors: | Murmu N Mitra S Das M Gomes A Vedasiromoni J R Ghosh M Bhattacharya M Ghosh P Biswas J Bhattacharya S Sur P |
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| Institution: | Chittaranjan National Cancer Institute, Calcutta, India. |
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| Abstract: | Two new boron compoumds, dihydroxy(oxybiguanido) boron (iii) hydrochloride monohydrate (HB) and guanidine biboric acid adduct (GB) were used in this study to observe the antitumor effect. Leukemic blast cells isolated from chronic myeloid leukemia (CML) patients showed significant cell growth inhibition within twentyfour hours. IC50 of GB and HB was 2mg/ml. The metabolically active cells were found to be inhibited by drug treatment as assessed by MTT test. Inhibition of 3H Thymidine incorporation also supported the above result. In this study we investigated the molecular mechanisms by which HB and GB induce apoptosis in immature blast cells. |
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