天津地区肺癌危险因素研究

目的 探讨天津地区肺癌危险因素,进一步为肺癌危险因素的监测提供依据。方法 采用病例-对照研究方法,调查年龄在30-75岁之间的、原发性肺癌患者193例和正常对照组259例,内容包括一般情况、生活居住环境、生活习惯、既往病史和家族病史等。通过非条件logistic回归模型进行单因素和多因素分析。结果 单因素分析显示,吸烟、被动吸烟、饮酒和恶性肿瘤家族史、职业均与肺癌有关。多因素分析结果显示,影响肺癌发病的主要因素为吸烟、被动吸烟、10年前月人均收入、10年前人均住房面积和体质指数(OR分别为3．302,1．193,1．003,1．067和0．913)。结论 吸烟和被动吸烟为肺癌的独立危险因素;随着10年前月人均收入和10年前人均住房面积的增加,肺癌发生的危险性增大;较高的体质指数则为肺癌的保护性因素。

Risk factors of lung cancer in Tianjin

Objective To investigate the risk factors of lung cancer in Tian jin and to provide evidence for further monitor there of. Methods A case-control study involving interviews with 193 new cases and 259 controls a g ed 30-76 years was carried out. Structured questionnaires were used to collect i nformation on general condition, living environment, living style, disease and f amily history, etc. Logistic regression model univariate and multivariate analys is were used to pick out the significant lung cancer risk factors. Results By monovariate analysis, risk factors such as smoking, passive smoking, drink ing, history of malignancy in family and occupation were found. By multivariate analysis, smoking, passive smoking, higher body mass index (BMI) and average inc ome and living space per capita ten years earlier were ascertained, t heir operations research (OR) values were 3.302, 1.193, 1.003, 1.067 and 0.9 13. Conclusion Smoking and passive smoking are independent risk factors of lung cancer. Monthly income per person and living space per person 10 years earlier are associated with ele vated risk of lung cancer. Higher body mass index has protective effects on lung cancer risk.