结合雌激素和7—甲基异炔诺酮对围绝经期和绝经期妇女脂蛋白及 …

目的 探讨结合雌激素（ＣＥ）和７－甲基异炔诺酮（ＯｒｇＯＤ１４）对围绝经期和绝经期妇女脂蛋白及载脂蛋白的影响。方法 ７４例围绝经期和绝经期患者分为：（１）ＣＥ组４６例,其中围绝经期１７例,绝经期２９例,按连续序贯方案每日口服ＣＥ０．６２５ｍｇ每日醋酸甲孕酮４ｍｇ;（２）ＯｒｇＯＤ１４组２８例,其中围绝经期９例,绝经期１９例,口服ＯｒｇＯＤ１４２．５ｍｇ,隔日１次,两组分别连续治疗２年,于用药前,用

Effect of conjugated estrogen and Org OD14 on serum lipoprotein and apolipoprotein in perimenopausal and postmenopausal women

OBJECTIVE: To determine the effect of conjugated estrogen and Org OD14 on serum lipoprotein and apolipoprotein in perimenopausal women. METHOD: 74 patients were divided into 2 groups: 46 were given conjugated estrogen 0.625 mg and medroxyprogesterone acetate 4 mg daily according to the continuous sequential, regimen 28 were given Org OD14 2.5 mg every two days. Serum lipoprotein and apolipoprotein estradiol and follicle stimulating hormone were measured before and (one and two years) after treatment. RESULTS: Total Cholesterol (TC), Triglycerin (TG), high density lipoprotein (HDL-C), Apolipoprotein AI (Apo AI), Apolipoprotein AII (Apo AII), Apolipoprotein B(Apo B), Apolipoprotein CII(Apo CII), Apolipoprotein CIII(Apo CIII), Lipoprotein(a)[Lp(a)] increased significantly (P < 0.05), while ApoB/AI, ApoCII/CIII decreased significantly(P < 0.05) in conjugated estrogen group. ApoCIII, E decreased, while ApoAI/AII increased significantly (P < 0.05) in Org OD14 group. After two years treatment, TC, HDL-C, ApoAI, ApoCIII, ApoE, TC, HDL-C, ApoAI, ApoCIII, ApoE of conjugated estrogen group were higher than those of Org OD14 group(P < 0.05), ApoCII/CIII of Conjugated estrogen was lower than that of Org OD14 group(P < 0.05). CONCLUSION: Postmenopausal hormone replacement therapy regulates the constitution of serum lipoprotein and apolipoprotein.