年龄、性别、膳食营养对人血清瘦素的影响

目的:探讨膳食营养及年龄、性别对血清瘦素(leptin,Lep)水平的影响。方法:选取158例17~72岁济南市社区居民作为研究对象,测量其身高、体重,检测其血清Lep浓度,被调查对象连续3d记录其摄入食物种类数量。所有数据用SPSS11.5软件包进行分析。结果:男性血清Lep平均浓度为8.38±6.31ng/ml,而女性血清Lep平均浓度为24.98±13.29ng/ml,女性血清Lep水平明显高于男性,约为男性的2~3倍,统计学意义显著。男性Lep水平和年龄呈正相关,女性Lep水平和年龄没有相关性。膳食营养因素中,校正体重指数(BMI)之前,男性和女性的Lep水平与膳食营养指标均无相关性。校正BMI的影响后,女性血清Lep水平与总脂肪摄入、单不饱和脂肪酸(MUFA)、多不饱和脂肪酸(PUFA)相关,而男性血清Lep水平和它们无相关性。结论:女性血清Lep水平明显高于男性。男性血清Lep水平与年龄相关,女性血清Lep与脂肪、MUFA、PUFA摄入相关。

EFFECTS OF AGE, SEX, DIET AND NUTRITION ON SERUM LEPTIN CONCENTRATION

Objective: To investigate the relationship between serum leptin concentration and diet nutrition, age and gender. Method: One hundred fifty-eight men and women aged 18-72 y were initially drawn from a community in Jinan City. The parameters measured included height, weight and serum leptin concentrations. In addition, a 3-d food record was used to represent usual food intake by the participants. Results: The mean serum leptin concentration in males was 8.38±6.31ng/ml, while in females 24.98±13.29 ng/ml. Serum leptin level in males was significantly correlated with age, but not in females. Respectively, serum leptin level in males and females were not correlated to dietary factors. After adjusted for BMI, serun leptin level in females was positively correlated with dietary intake of fat, MUFA and PUFA. Conclusion: Serum leptin level in female is higher than that in male. Age is correlated to serum leptin level in males. The relation of dietary intake of fat, MUFA and PUFA to serum leptin concentration only existed in women.