药物导电压敏胶的制备及其体外透皮释放试验

目的:考察固化在导电压敏胶中的吲哚美辛在低频脉冲电流作用下的释放现象,试图将透皮给药治疗体系与低频脉冲电刺激相结合来提高疗效。方法:利用紫外光固化技术将吲哚美辛直接固化在导电压敏胶中,通过药物体外透皮释放模型测定吲哚美辛的释放。结果:光引发剂对压敏胶固化有重要影响,使用混合光引发剂有利于固化;压敏胶厚度不宜超过2cm;吲哚美辛药量增加,对预聚体配方的固化及保存有影响,吲哚美辛合适用量约为0.50％。结论:制得了固化良好、具有一定粘性和可多次使用的含药导电压敏胶;低频脉冲电流刺激下(正、负极),压敏胶中吲哚美辛的释放加快。

Study on vitro transdermal release of indomethacinum in conductive pressure sensitive adhesive

OBJECTIVE: Explain the release behavior of indomethacinum cured in conductive pressure sensitive adhesive as instimulated with electric current and in static conditions;combine traditional cure by transdermal releasing with that by stimulating with low frequence pluse elective current to raise curing effectiveness. METHODS: Cure indomethacinum directly in conductive pressure sensitive adhesive by UV. Determin the release of the drug according to the model of transcutaneous release in vitro. RESULTS: Initiator influences the cure of pressure adhesive markedly. The use of mixed initiator is benefitial to the cure of adhesive; the thickness of adhesive should be less than 2cm.The cure and preservation of sample is affected by increasing the content of indomethacinum. The preferred content of indomethacium is 0.50% .CONCLUSION: Well cured, sticky and repeatedly utilized drug - containing conductive pressure adhesive was prepared. The release of indomethacium cured in adhesive was improved as stimulating with low frequence pulse electric current ( anode, cathode).