| CXCR4在肺癌组织中的表达及临床意义 |
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| 引用本文： | 苏丽萍,张进平,陈晋,王缨,熊思东. CXCR4在肺癌组织中的表达及临床意义[J]. 中国癌症杂志, 2005, 15(2): 97-100 |
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| 作者姓名： | 苏丽萍 张进平 陈晋 王缨 熊思东 |
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| 作者单位： | 复旦大学上海医学院免疫系,教育部分子医学重点实验室,上海基因免疫和疫苗研究中心,上海,200032 |
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| 基金项目： | 国家教育部科学技术重点项目(03063)，国家杰出青年科学基金(39925031)。 |
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| 摘 要： | 目的：探讨CXCR4在肺癌组织中的表达及其临床意义。方法：分别通过定量RT-PCR和免疫组织化学方法检测36例肺癌、10例癌旁正常肺组织中CXCR4的表达。结果：与癌旁正常肺组织相比，36例中34例肺癌组织表达较高水平的CXCR4。CXCR4的高表达与肺癌患者的年龄、性别、肺癌组织类型和分化程度无关，而与临床转移(淋巴结转移和局部浸润)有关。结论：CXCR4的上调表达见于肺癌的发生早期，其高水平与肺癌转移有关。
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| 关 键 词： | 肺癌 CXCR4 表达 |
| 文章编号： | 1007-3639(2005)02-0097-04 |
| 修稿时间： | 2004-10-08 |
Expression of CXCR4 in lung cancer and its significance |
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| SU Li-ping,ZHANG Jin-ping,CHEN Jin,et al. Expression of CXCR4 in lung cancer and its significance[J]. China Oncology, 2005, 15(2): 97-100 |
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| Authors: | SU Li-ping ZHANG Jin-ping CHEN Jin et al |
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| Abstract: | Purpose:To investigate the expression and significance of CXCR4 in human lung cancer. Methods:Real-time RT-PCR and immunohistochemistry were performed to detect the expression of CXCR4 on 36 lung cancer specimens and 10 normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue. Results:34 of 36 cases showed positive staining of CXCR4 protein compared with normal lung specimens.CXCR4 expression was independent of pathological type or histological grade. However, in all examined cases, higher expression of CXCR4 tended to be detected in the tumor specimens with lymph node metastasis or regional invasion. Conclusions:Up-regulated expression of CXCR4 was detected in the early stage of lung cancer, and high-level expression of CXCR4 was associated with lung cancer having metastasis. |
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| Keywords: | lung cancer CXCR4 expression |
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