乳腺癌中P21基因产物的表达及其临床意义

目的:通过探讨P21的表达与乳腺癌发生、发展、病理特征、淋巴结转移、预后的关系,为临床诊断和治疗提供新的参考指标。方法:应用免疫组化SABC法检测41例乳腺癌组织中P21基因产物的表达。结果:P21阳性产物染色定位于细胞核中,在乳腺癌中阳性率为80.5%。P21表达与ER、PR、淋巴结转移无相关性,与患者5年生存率密切相关(P>0.05)。结论:P21表达可作为判断乳腺癌预后的一个重要指标。

Expression of P21 protein in breast cancer and its significance

Objective To study the levels of P21protein expression in human breast cancer and its relationship with pathogenesis,development,pathological type,lymph node metastasis and clinical signifi-cance.Method:Immunohistochmical SABC method was used to detect the P21protein expression in41breast cancer tissues.Results:The immunochemical positive reactivity pattern of the anti-P21antibody was identified in the nucleus and its positive rate was80.5%.The P21expression was associated with five-year survival rate but not correlated with age,ER,PR andlymph node metastasis.Conclusion:P21plays an impor-tant role in the cell cycle and might be an important indicative item for the prognosis of breast cancer.