| 不同频率电针对延髓头端腹内侧区神经元电活动的影响 |
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| 引用本文： | 敖鸣芳 魏劲波. 不同频率电针对延髓头端腹内侧区神经元电活动的影响[J]. 针刺研究, 1996, 21(4): 41-45 |
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| 作者姓名： | 敖鸣芳 魏劲波 |
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| 作者单位： | 湖北医科大学第二附属医院(敖鸣芳),湖北医科大学生理学教研室!武汉430071(魏劲波,谭振军,胡祁生,汤剑青) |
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| 摘 要： | 采用玻璃微电极,细胞外记录大鼠延髓头端腹内侧区（RVM）神经元电活动的变化。发现2Hz和10Hz两种频率电针穴位时均能增强痛兴奋神经元的自发放电,并抑制其增频反应;2Hz对增频反应的抑制效应可被纳洛酮完全阻断,但10Hz的效应仅被纳洛酮部分阻断。提示：2Hz和10Hz的电针均能激活RVM中的痛兴奋神经元,并主要是通过内源性阿片肽发挥镇痛效应,但10Hz的作用除阿片系统外,可能还有非阿片系统的参与。
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| 关 键 词： | 阿片肽 针刺镇痛 延髓头端腹内侧区 |
The Influence of Electroacupuncture with Different Frequencies on the Discharges of Neurons in Rostral Ventromedial Medulla on Rats |
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| Abstract: | The experiments were carried out on rats, anesthetized with urethan and paralyed with tubocuraine. Stainless steel needles were inserted into bilateral "Zusanli" points. The unit discharges of RVM neurons were recorded extracellalarly by microelectrode. The searching of nociceptive neurons and processing of data were operated automatically by a real time control system. The results were as follow:1. The pain response of excitatory neurons could be inhibited by 2Hz EA (n = 15/22, P< 0.01),the mean inhibition rate was 32. 40%.2. The inhibitory effects of 2Hz were completely blocked by naloxone pretreated (n = 5/5, P< 0.01).3. The pain response of excitatory neurons could be inhibited by 10Hz EA(n = 10/ 13, P<0. 01),the mean inhibition rate was 49. 06%.4. The inhibitory effects of 10Hz EA were partially blocked by naloxone pretreated (n = 5/5, P<0.01).5. Both 2Hz and 10Hz EA could enhance the spontaneous discharges of excitatory neurons in RVM, and the percentage of change in the frequency was 62. 45% and 112. 02 % respectively.6. Neither 2Hz nor 10Hz EA could obviously influence the spontaneous activity of inhibitory neurons in RVM.The results suggest that both 2Hz and 10Hz EA could activate excitatory neurons in RVM, which may suppress nociceptive transmission via opioid mechanism |
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