5-羟色胺和生长抑素对P物质及慢痛引起的脊髓背角神经元电活动的影响 |
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引用本文: | 阮怀珍 李希成. 5-羟色胺和生长抑素对P物质及慢痛引起的脊髓背角神经元电活动的影响[J]. 针刺研究, 1996, 21(3): 27-31 |
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作者姓名: | 阮怀珍 李希成 |
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作者单位: | 第三军医大学生理教研室!重庆,630038,第三军医大学生理教研室!重庆,630038,第三军医大学组胚教研室 |
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基金项目: | 全军“八五”攻关课题青年基金 |
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摘 要: | 本研究用多管微电极细胞外记录和离子微电泳方法,以Wistar大鼠为实验对象,观察了P物质(SP)对脊髓背角神经元自发放电和慢性伤害性痛放电的影响以及与5-羟色胺(5-HT)和生长抑素(SOM)的关系。结果表明:(1)电泳SP可使脊髓背角神经元单位放电增多。(2)电泳SP又可抑制福尔马林(Formalin)引起的神经元慢性伤害性痛放电。(3)电泳5-HT和SOM可抑制SP及慢痛诱发的脊髓背角神经元放电。上述结果提示:在痛觉调制过程中,脊髓内SP起着传递痛觉信息和镇痛的双重作用,5-HT和SOM可通过抑制SP的效应,参与痛觉调制。
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关 键 词: | P物质 5-羟色胺 生长抑素 脊髓背角 离子电泳 |
Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn |
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Abstract: | The effects of SP on the electric activities of neurons of spinal dorsal horn and the influence of 5-HT, somatostat in (SOM ) on the effects of SP were observed in anesthet ized rats with multimicropipeteand iontophoresis techniques. It was found that. (1 ) The m icroiontop horetically administrating of SPcould increase spinal dorsal horn unit discharge. (2) The noxious electrical activity of neurons inducedby formalin could be inhibited by microiontophoretically applied SP. (3 ) The mi croiontophoretically ad -ministrating of 5-HT and SOM could inhibit the SP and formalin evoked unit discharge of neurons inspinal dorsal horn. It was suggested that SP took a double-effect part in modulation of pain transmissionand analgesia in spinal cord, 5-HT and SOM inhibited the effect of SP and participated in pain modula-tion of SP. |
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