急性脑梗塞患者VIP,SS,PP改变及电针对其的影响

血管活性肠肽（VIP）、生长抑素（SS）及胰多肽（PP）广泛存在于胃肠道及神经系统中，具有激素及神经介质或神经调节物质作用。缺血性脑血管病时，血及脑脊液中这三种神经肽的改变，报导较少。本文报导急性脑梗塞病患者血VIP、SS和PP及脑脊液VIP和SS改变，及其电针对这三种神经肽的影响。64例急性脑梗塞患者，电针治疗穴位为曲池、外关、环跳、足三里；常规治疗包括低分子右旋糖酐、复方丹参等药物治疗。治疗前后，采集血及脑脊液标本。用放免法测定VIP、SS及PP。结果表明，急性脑梗塞患者中，脑脊液中VIP含量显著低于对照组；血浆SS水平较对照组略低；血浆PP水平显著高于对照组。在电针治疗后，治疗有效的患者，脑脊液中VIP恢复至正常水平，血浆及脑脊液SS水平显著升高，血浆PP水平无明显改变。提出电针可能通过调整中枢神经系统中VIP、SS紊乱而发挥治疗作用。

The Changes of Vasoactive Intestinal Peptide Somatostatin and Pancreatic Polypeptide in Blood and CSF of Acute Cerebral Infarction Patients and the Effect of Acupuncture on Them

VIP, SS and PP which exist in gastrointestinal tract and CNS might be to play an important role in nervous system as neurotransmitters of neuromediaters. There have been a few of reports about their changes in plasma and CSF in ICVD. The effects of acupuncture, which was used in treatment of ICVD with good efficiency, on VIP, SS ans PP have not been known. For researching their changes in ICVD and effects of electro-acupuncture on them, and finding the mechanism of acupuncture in treatment of ICVD, the study was performed. The levels of VIP, SS and PP in 64 patients with acute cerebral infarction were deterrnined. The points of acupuncture were Quchi (LI 12 ), Waiguan (SJ 5), Huantiao (BG 30), and Zusanli(ST 36). The routine treatment included dextran, nicotinic acid, aspirin, dipyridamole and radix salviae miltiorrnizae composita. The CSF and blood were taken before the begining of treatments and alter a course of treatment. The levels of VIP, SS and PP were meassured by radioimmunoassay.Results showed the level of CSF VIP in the patients was significantly lower as compared with controls.The level of plasma SS in the patients was lower, but the difference was not significant as compared with controls, and level of plasma PP in the patients was significantly increased when it was compared with controls. After electro-acupuncture treatment, in patients with good efficiency, CSF VIP recovered to normal level and the levels of plasma and CSF SS were significantly increased. while the level of plasma PP had no significant change. The results suggest that acupuncture might regulate the disturbances of metabolism of VIP and SS in CNS