| 磷酸二酯酶9及其抑制剂的研究进展 |
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| 引用本文： | 李杰,陈浩,陈国良.磷酸二酯酶9及其抑制剂的研究进展[J].沈阳药科大学学报,2009,26(5):409-414. |
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| 作者姓名： | 李杰 陈浩 陈国良 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016
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| 摘 要： | 目的为磷酸二酯酶9(phosphodiesterase 9,PDE 9)的研究与开发提供参考。方法查阅PDE 9及其抑制剂的研究开发现状的多篇相关文献,进行整理和归纳。结果大多数PDE9抑制剂都能选择性地在体外和体内抑制PDE 9,并取得较好的药理活性。结论PDE 9将成为药物治疗的新一代靶点,其抑制剂的研究与开发具有广阔的发展前景。
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| 关 键 词： | 磷酸二酯酶9 磷酸二酯酶9抑制剂 神经系统失调 心血管疾病 |
| 收稿时间： | 2008-5-19 |
Research progress on phosphodiesterase 9 and its inhibitors |
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| LI Jie,CHEN Hao,CHEN Guo-liang.Research progress on phosphodiesterase 9 and its inhibitors[J].Journal of Shenyang Pharmaceutical University,2009,26(5):409-414. |
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| Authors: | LI Jie CHEN Hao CHEN Guo-liang |
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| Institution: | (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) |
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| Abstract: | Objective To review the recent developments in the research of phosphodiesterase 9 (PDE 9) and its inhibitors and provide a reference for the further research and development of them. Methods The trends of research and development for PDE 9 and its inhibitors were summarized on the basis of related literatures. Results Most of PDE 9 inhibitors can inhibit PDE 9 in vitro and in vivo selectively and have good pharmacological activities. Conclusions PDE 9 will become a new generation of drug therapy target, the research of its inhibitors has exciting prospect. |
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| Keywords: | phosphodiesterase 9 (PDE 9) phosphodiesterase 9 inhibitor nervous system disorder cardiovascular disease |
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