CF加大剂量5-FU持续滴注联合放疗治疗晚期直肠癌30例临床分析

目的 评价大剂量醛氢叶酸(CF)加氟脲嘧啶(5-FU)持续48 h滴注联合放疗方案治疗晚期直肠癌的疗效及毒副反应,探讨晚期直肠癌较合理的治疗方案.方法 对30例晚期直肠癌患者采用大剂量CF(200 mg/m2)+5-FU(3.2 g/m2)持续48 h滴注联合放疗,化疗平均2.67个疗程.结果完全缓解(CR)4例,部分缓解(PR)14例,稳定(NC)11例,进展(PD)1例,总有效率为60%,主要的毒副反应为恶心、呕吐、口腔黏膜炎、骨髓抑制及脱发.结论大剂量CF+5-FU持续48 h滴注联合放疗治疗晚期直肠癌疗效好、毒副反应轻.

Continuous infusion of calcium folinate plus 5-fluorouracil bolus combining with radiotherapy for advanced rectal carcinoma in 30 cases

Objective To assess the anti-tumor efficacy and safety of 48 hours’ continuous infusion of high-doesfolinic acid plus 5-fluorouracil bolus combining with radiotherapy for advanced rectal carcinoma.Methods Thirty patients with advanced rectal carcinoma were treated with 48 hours’ continuous infusion of high-does-folinic acid(200 mg/m2) plus 5-fluorouracil bolus(3.2 g/m2)combining with radiotherapy,with the 2.67 courses on average.Results Complete remission of the tumor was found in 4 cases,partial remission in 14 cases,unchanged in 11 cases,and progression in 1 case.The total effective rate was 60%.The main side effects included nausea and vomiting,mucositis,bone marrow suppression and alopecia.All side effects were tolerable and mild except for nausea and vomiting.Conclusion Continuous infusion of high-does-folinic acid plus 5-fluorouracil bolus combining with radiotherapy is proved as a safe and effective therapy for patients with advanced rectal carcinoma.