Lack of long-term monoamine depletions following repeated or continuous exposure to cocaine |
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Authors: | Mark S. Kleven William L. Woolverton Lewis S. Seiden |
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Affiliation: | Department of Pharmacology, University of Chicago, IL 60637. |
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Abstract: | Cocaine was administered to rats for prolonged periods either by repeated injections (10 mg/kg twice daily for 10 days and 12.5 mg/kg 8 times daily for 10 days) or by continuous intravenous infusion (100 mg/kg/day for 21 days). None of the regimens produced long-lasting depletions of dopamine (DA), serotonin (5-HT), or major metabolites in striatum, hippocampus, hypothalamus, or somatosensory cortex. These results suggest that prolonged exposure to cocaine does not produce neurotoxicity like that observed with d-amphetamine or d-methylamphetamine. |
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Keywords: | Cocaine Neurotoxicity Dopamine Serotonin Rat |
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