复方螺旋藻片对高血脂症小鼠血脂的影响

目的：观察复方螺旋藻片（FST）对高脂血症小鼠血脂的影响。方法：用FST1.5mg/kg,3g/kg分别灌胃给予高脂血症小鼠，连续14d后，眼眶取血测血脂。结果：与高脂血症模型对照组相比，FST高、低剂量能显著降低血清TC、TG和LDL－C水平，明显升高血清HDL－C水平与HDL－C／TC比值。同时FST还能升高血清apoAI并降低apoB(但FST 1.5g/kg对apoB无明显影响）。结论：FST能明显降低高脂血症小鼠血脂水平，并对载脂蛋白有一定的调节作用。

Effect of Spirulina Compound Tablet on Serum Lipids in Hyperlipidemic Mice

OBJECTIVE:To study the effect of Spirulina Compound Tablet(FST) on the level of serum lipids in hyperlipidemic mice.METHODS:The experimental hyperlipidemic mice were divided into four groups.Among them,two groups were treated with FST 1.5g/kg,3g/kg respectively by ig administration,and one group was given lipanthyl 0.05g/kg by ig administration as the positive drug control,another group was received physiological saline by ig administration as the hyperlipidemic control.The treatment were consecutively carried out for 14 days.Then the serum lipids of each group were determined with automatic biochemistry analysor.RESULTS:Compared with the hyperlipidemic control group,it was found that FST could significantly decrease the level of total serum cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL C),as well as remarkably increase the content of serum high density lipoprotein cholesterol(HDL C) and the value of HDL C/TC in the hyperlipidemic mice.Furthermore,the results also showed that FST could obviously raise the concentration of the serum apolipoproteinAI(apoAI) and reduce the concentration of apolipoproteinB(apoB)(Whereas FST 1.5g/kg had no significant effect on apoB).CONCLUSION:FST could remarkably decrease the content of serum lipids and regulate the apolipoprotein in the hyperlipidemic mice.