全身炎症反应综合征患儿T细胞亚群变化及其临床意义

目的 探讨新生儿T细胞亚群在全身炎症反应综合征(SIRS)中的作用。方法 观察组选择非SIRS患儿24例，SIRS患儿27例，对照组选择健康新生儿20例。在病情危重期测定T细胞亚群，并观察病情的演变。结果 SIRS组及非SIRS组CD3、CD4、CD8均低于对照组。SIRS组中，死亡者CD3、CD8低于存活者，CD4/CD8及器官功能不全数均高于存活者。SIRS组病死率高于非SIRS组。结论 由于新生儿T淋巴细胞功能不完善，易受各种不利因素的影响。功能被抑制，细胞凋亡增加，影响细菌、病毒的清除，故导致全身器官功能衰竭。

Changes and significance of T lymphocyte subsets in neonate with SIRS

Objective To explore the changs and significance of T lymphocyte subsets in neonate with SIRS Methods The observed groups included 24 cases without SIRS and 27 cases with SIRS and the control group included 20 healthy neonates T lymphocyte subsets were examined in the observed groups at the crisis time and the control group At the same time the state of illness was observed Results The percentages of CD 3,CD 4 and CD 8 in the observed groups were lower than in the control group The percentages of CD 3,CD 8 in the SIRS died group were lower than in the SIRS lived group while CD 4/CD 8 and the number of organ with lacking function were higher than the SIRS lived group The death rate in SIRS group was higher than in the non SIRS group Conclusion The function of T lymphocyte is not perfect and liable to be affected by all kinds of factor The apoptosis increase and the bacterium isn't clear which result to MODS