| 超微细粉小复方等对大鼠心肌缺血/再灌注损伤能量代谢的影响研究 |
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| 引用本文： | 楼丹飞,王骁,曹敏,王佑华,周端. 超微细粉小复方等对大鼠心肌缺血/再灌注损伤能量代谢的影响研究[J]. 中华中医药学刊, 2011, 0(10): 2277-2279 |
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| 作者姓名： | 楼丹飞 王骁 曹敏 王佑华 周端 |
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| 作者单位： | 上海市中医医院;上海中医药大学附属龙华医院; |
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| 基金项目： | 上海市引进技术的吸收与创新计划资助项目(YY-16) |
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| 摘 要： | 目的:观察具有益气活血通痹作用的中药超微细粉小复方对大鼠心肌缺血/再灌注损伤的影响。方法:63只大鼠随机分假手术组(Sham)、模型组(Model)、中粉组(Z)、超微细粉组(X)、煎剂组(J)、麝香保心丸组(SX)等7组,灌胃14天,冠脉结扎60min联合Langendroff灌流120min复制心肌缺血/再灌注模型,采用生化方法检测各组大鼠心肌Na+-K+-ATPase、Ca2+-Mg2+-ATPase、FFA含量。结果:与模型组相比,益气活血通痹小复方各组均能降低心肌FFA含量(P<0.01),其中以中粉组、超微细粉组效果最佳。中粉组、超微细粉组能升高心肌Na+-K+-ATPase含量、Ca2+-Mg2+-ATPase含量(P<0.01),煎剂组能升高Ca2+-Mg2+-ATPase含量(P<0.05)。结论:益气活血通痹小复方可能通过改善心肌能量代谢减轻心肌缺血/再灌注损伤,以中粉组、超微细粉组效果最佳。
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| 关 键 词： | 心肌缺血/再灌注损伤 超微细粉小复方 益气活血通痹 能量代谢 |
Research of the effect of the small micropowder compound recipe on energy metabolism with myocardial schemia-reperfusion injury in rats |
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| LOU Dan-fei,WANG Xiao,CAO Min,WANG You-hua,ZHOU Duan. Research of the effect of the small micropowder compound recipe on energy metabolism with myocardial schemia-reperfusion injury in rats[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(10): 2277-2279 |
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| Authors: | LOU Dan-fei WANG Xiao CAO Min WANG You-hua ZHOU Duan |
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| Affiliation: | LOU Dan-fei1,WANG Xiao2,CAO Min2,WANG You-hua2,ZHOU Duan2(1.Shanghai Municiple Hospital of TCM,Shanghai 200071,China,2.Longhua hospital affiliated to Shanghai Univercity of TCM,Shanghai 200032,China) |
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| Abstract: | Objective: To observe the effect of Yiqi Huoxue Tongbi small micropowder compound recipe on myocardial schemia-reperfusion injury in rats.Methods: 63 SD rats were divided into 7 groups randomly:sham group,model group,thick powder group(C),mediate powder group(Z),micropowder group(X),decoction group(J) and Shexiang Baoxin Pills group(SX).Rats were fed 14 days,the model of myocardial schemia-reperfusion injury was established on rats by coronary artery ligation 60min and Langendorff apparatus 120min.Na+-K+-AT... |
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| Keywords: | myocardial schemia-reperfusion injury small micropowder compound recipe Yiqi Huoxue Tongbi energy metabolism |
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