| 岩柏草总黄酮对肝纤维化大鼠抗氧化系统的影响 |
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| 引用本文： | 刘寿荣,王福根,包建峰,沈益琴. 岩柏草总黄酮对肝纤维化大鼠抗氧化系统的影响[J]. 中华中医药学刊, 2011, 0(11): 2400-2401 |
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| 作者姓名： | 刘寿荣 王福根 包建峰 沈益琴 |
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| 作者单位： | 浙江省中医药大学附属第六医院; |
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| 摘 要： | 目的:探讨岩柏草总黄酮对肝纤维化大鼠抗氧化系统的影响。方法:采用50%四氯化碳(CCl4)皮下注射8周,在造模同时分别灌胃15、30、60mg/kg剂量岩柏草总黄酮混悬液,并以水飞蓟宾为实验对照。8周后处死大鼠,对大鼠肝脏纤维化评分,并检测血清和肝组织各指标,对岩柏草总黄酮防治肝纤维化疗效进行评价。结果 CCl4造模结束后,大鼠肝组织病理结果显示其肝纤维化处于Ⅲ-Ⅳ期;与模型组比较,岩柏草总黄酮能显著降低大鼠血清ALT、AST和肝组织中MDA,明显升高肝组织中SOD、GSH、CAT,显著改善大鼠肝纤维化的抗氧化系统。结论岩柏草总黄酮对CCl4诱导的肝纤维化大鼠抗氧化系统有较好的保护作用。
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| 关 键 词： | 肝纤维化 四氯化碳 岩柏草 抗氧化系统 |
Influence of Total Flavonoids of Selaginella moellendorfii Hieron on Antioxidant System of Experimental Liver Fbrosis in Rat |
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| LIU Shou-rong,WANG Fu-gen,BAO Jian-feng,SHEN Yi-qin. Influence of Total Flavonoids of Selaginella moellendorfii Hieron on Antioxidant System of Experimental Liver Fbrosis in Rat[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(11): 2400-2401 |
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| Authors: | LIU Shou-rong WANG Fu-gen BAO Jian-feng SHEN Yi-qin |
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| Affiliation: | LIU Shou-rong,WANG Fu-gen,BAO Jian-feng,SHEN Yi-qin(The Sixth Hospital Affiliated to Zhe Jiang University of Traditional Chinese Medicine,Hangzhou 310014,Zhejiang,China) |
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| Abstract: | Objective: To explore the influence of selaginella moellendorfii hieron on Antioxidant System of experimental liver fbrosis in rat.Method: Liver fbrosis models were made by carbon tetrachloride(CCl4),and then were intragastric administered with total flavonoids of Selaginella moellendorfii Hieron.All the rats were killed after 8 weeks of administration,the role of total flavonoids in treatment of liver fibrosis was evaluated.Result: The result showed that total flavonoids of selaginella moellendorfii hieron... |
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| Keywords: | liver fibrosis carbon tetrachloride selaginella moellendorfii hieron antioxidant system |
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