| 溃结安康汤对溃疡性结肠炎大鼠结肠组织氧自由基影响的实验研究 |
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| 引用本文： | 陶弘武,柳越冬. 溃结安康汤对溃疡性结肠炎大鼠结肠组织氧自由基影响的实验研究[J]. 中华中医药学刊, 2011, 0(8): 1834-1835 |
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| 作者姓名： | 陶弘武 柳越冬 |
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| 作者单位： | 辽宁中医药大学附属医院;沈阳军区总医院博士后工作站;辽宁中医药大学附属第四医院; |
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| 基金项目： | 辽宁省教育厅资助项目(L2010370) |
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| 摘 要： | 目的:研究溃结安康汤对溃疡性结肠炎大鼠结肠组织氧自由基影响及其作用机制。方法:健康Wist-ar大鼠,随机分为空白对照组、模型组、补脾益肠丸组、SASP组、溃结安康汤组。TNBS/乙醇法建立溃疡性结肠炎大鼠模型。分组灌胃治疗后,检测溃结大鼠结肠组织氧自由基MDA含量和SOD活性。结果:模型组与正常组比较,大鼠结肠组织中的MDA含量明显升高,SOD活性明显降低,具有统计学意义(P<0.05);补脾益肠丸组、SASP组、溃结安康汤组与模型组比较,MDA含量明显下降,SOD活性明显增强,具有统计学意义(P<0.05);溃结安康汤组与补脾益肠丸组、SASP组比较,MDA含量下降,SOD活性明显增强,具有统计学意义(P<0.05)。结论:溃结安康汤可以降低溃疡性结肠炎大鼠结肠组织MDA含量、增加SOD活性。
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| 关 键 词： | 溃结安康汤 溃疡性结肠炎 MDA SOD |
Research about the influence of Kuijieankang Decoction to Rats'SOD&MDA with Ulcerative Colitis |
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| TAO Hong-wu,LIU Yue-dong. Research about the influence of Kuijieankang Decoction to Rats'SOD&MDA with Ulcerative Colitis[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(8): 1834-1835 |
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| Authors: | TAO Hong-wu LIU Yue-dong |
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| Affiliation: | TAO Hong-wu1,LIU Yue-dong2(1.The Affiliated Hospital of Liaoning TCM University,Shenyang 110032,2.Post-Doctoral Research Center,The Main Hospital of Shenyang Military Region,The 4th Affiliated Hospital of Liaoning TCM University,Shenyang 110101) |
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| Abstract: | Objective: To research into the influence of Kuijieankang decoction to rats'SOD&MDA with ulcerative colitis and its mechanism of action.Methods: Some healthy Wistar rats were randomly divided into control group,model group,Bupiyichang pill group,SASP group,and Kuijieankang decoction group.The rat model of ulcerative colitis was established by TNBS/ethanol method.Detecting SOD and MDA activity of rats'colon tissue with ulcerative colitis after intragastric administration.Result: Comparing with normal group,t... |
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| Keywords: | Kuijieankang decoction ulcerative colitis MDA SOD |
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