| 益气补肾中药对自然流产模型小鼠NK细胞的影响 |
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| 引用本文： | 叶平,黄丹云,胡蓝雅文,陈雪君. 益气补肾中药对自然流产模型小鼠NK细胞的影响[J]. 中华中医药学刊, 2011, 0(9): 2032-2033 |
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| 作者姓名： | 叶平 黄丹云 胡蓝雅文 陈雪君 |
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| 作者单位： | 浙江中医药大学第一临床医学院;浙江省中医院妇科; |
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| 基金项目： | 浙江省教育厅资助项目(20071142) |
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| 摘 要： | 目的:观察益气补肾中药对自然流产模型小鼠脾脏、母胎界面组织NK细胞表达的影响。方法:以雌性CBA/J和雄性DBA/2为模型,孕0天始灌服益气补肾中药,并与环孢素A(CSA)对照,孕9天、14天流式分析脾脏、母胎界面NK细胞的表达。结果:孕9天各用药组NK细胞在脾脏及母胎界面的表达较阴性对照组明显降低(P<0.01或P<0.05);孕14天各用药组NK细胞在脾脏的表达较阴性对照组明显降低(P<0.05);孕14天中西医结合组NK细胞在母胎界面的表达较阴性对照组明显降低(P<0.05),而中药组、CSA组与阴性对照组比较无明显差异(P>0.05)。结论:益气补肾中药可下调自然流产模型小鼠孕9天及14天脾脏NK细胞表达及孕9天母胎界面NK细胞表达;益气补肾中药与CSA协同可下调自然流产模型小鼠孕14天母胎界面NK细胞表达,具有一定的免疫调节作用。
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| 关 键 词： | 益气补肾 NK细胞 自然流产 |
The Effect of the Traditional Chinese Medicine with Function of Invigorating Qi and Tonifying Kidney on Natural Killer Cells in Abortion-prone Mice |
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| YE Ping,,HUANG Dan-yun,HU Lanyawen,CHEN Xue-jun. The Effect of the Traditional Chinese Medicine with Function of Invigorating Qi and Tonifying Kidney on Natural Killer Cells in Abortion-prone Mice[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(9): 2032-2033 |
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| Authors: | YE Ping HUANG Dan-yun HU Lanyawen CHEN Xue-jun |
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| Affiliation: | YE Ping1,2,HUANG Dan-yun1,HU Lanyawen1,CHEN Xue-jun1 (1.Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China,2.Department of Gynaecology,Chinese Traditional Hospital of Zhejiang,China) |
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| Abstract: | Objective: To observe the effect of the traditional Chinese medicine(TCM) with function of invigorating Qi and tonifying kidney on the expression of natural killer(NK) cells at spleen and maternal-fetal interface in abortion-prone mice during pregnancy.Methods: CBA female mice were mated to DBA /2 male mice as an abortion-prone model.Drenched the TCM decoction we've made with function of invigorating Qi and tonifying kidney everyday since day 0 of gestation;And compared with Cyclosporin A.On the 9th and 14t... |
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| Keywords: | invigorating Qi and tonifying kidney NK cell spontaneous abortion |
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