| 舒乐冲剂对脑卒中后抑郁模型大鼠NE、5-HT水平的影响 |
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| 引用本文： | 李春红,赵世珂,李衍滨. 舒乐冲剂对脑卒中后抑郁模型大鼠NE、5-HT水平的影响[J]. 中华中医药学刊, 2011, 0(9): 2107-2108 |
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| 作者姓名： | 李春红 赵世珂 李衍滨 |
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| 作者单位： | 济南市中医医院;山东省千佛山医院; |
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| 基金项目： | 济南市科技局资助项目(20070701089-2) |
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| 摘 要： | 目的:探讨舒乐冲剂对脑卒中后抑郁(PSD)模型大鼠单胺递质NE、5-HT的影响。方法:采用电凝法制备局灶性脑缺血大鼠模型,在此基础上复合孤养、应激处理制备PSD大鼠模型,ELISA检测大鼠脑组织NE、5-HT浓度。结果:舒乐冲剂可提高PSD大鼠脑组织NE和5-HT含量,尤以提高NE为著。结论:舒乐冲剂对PSD大鼠脑内单胺递质降低有改善作用,这可能是其治疗PSD的机制之一。
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| 关 键 词： | 舒乐冲剂 脑卒中后抑郁 NE 5-HT 实验研究 |
Effect of Shu-Le Granule on the Levels of NE,5-HT in Cerebral of Post-stroke Depression Rats |
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| LI Chun-hong,ZHAO Shi-ke,LI Yan-bin. Effect of Shu-Le Granule on the Levels of NE,5-HT in Cerebral of Post-stroke Depression Rats[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(9): 2107-2108 |
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| Authors: | LI Chun-hong ZHAO Shi-ke LI Yan-bin |
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| Affiliation: | LI Chun-hong1,ZHAO Shi-ke1,LI Yan-bin2(1.Jinan Hospital of Traditional Chinese Medicine,Jinan 250012,Shandong,China,2.Shandong Provincial Qianfoshan Hospital,Jinan 250014,China) |
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| Abstract: | Objective: To observe the effect of Shu-Le granule on the levels of NE,5-HT in Cerebral of Post-stroke depression(PSD) Rats.Methonds:The rat models of local cerebral ischemia were using electrocoagulation methond.Then treated the rats with combined methonds of isolation feed and irritable stimulation.At last by ELISA to detected the NE,5-HT's levels in the rat's brain.Results: Shu-Le granules can increased the NE,5-HT's level of the PSD rats,especially to the level of NE.Conclusion: Shu-Le granule can impro... |
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| Keywords: | Shu-Le granules Post-stroke depression NE 5-HT Experimental study |
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