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Urinary melatonin excretion throughout the ovarian cycle in menstrually related migraine |
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| Authors: | G Murialdo S Fonzi P Costelli GP Solinas C Parodi S Marabini M Fanciullacci A Polleri |
| Institution: | Interuniversity Centre, Neurochemistry and Clinical Pharmacology of Idiopathic Headache. Genoa Unit: Department of EndocrinologicaI and Metabolic Sciences, University of Genoa, Italy and; Interuniversity Centre, Neurochemistry and Clinical Pharmacology of Idiopathic Headache. Florence Unit: Institute of Internal Medicine and Therapeutics IV, Headache Centre, Florence, Italy |
| Abstract: | Nocturnal urinary melatonin excretion was significantly decreased throughout an ovarian cycle in 12 migraine without aura patients compared to 8 healthy controls. Normal increases in urinary melatonin excretion during the luteal phase was less pronounced in the migraine patients. Melatonin excretion was further decreased during headache. The data indicate impaired pineal function in migraine. |
| Keywords: | Migraine ovarian cycle pain effects urinary melatonin |