膜型基质金属蛋白酶-1与肿瘤的侵袭和转移的研究进展

基质金属蛋白酶在肿瘤侵袭和转移中起着非常重要作用,而膜型基质金属蛋白酶是一类基质金属蛋白酶家族的新成员,其中膜型基质金属蛋白酶-1是研究最深、意义极为重要的一种,它直接或间接降解细胞外基质中的多种成分,通过调节多种细胞效应分子,影响肿瘤细胞的浸润、转移以及血管生成等过程,在肿瘤的浸润和转移的过程中有重要作用.

Research progress of membrane type 1 matrix metalloproteinase in tumor invasion and metastasis

Matrix metalloproteinases play an important role in the tumor invasion and metastasis. Membrane type matrix metalloproteinase is a new member of matrix metalloproteinase family, among which membrane type 1 matrix metalloproteinase is the most extensive and extremely important. It directly or indirectly degrades various components of extracellular matrix, has an impact on the process of tumor invasion,metastasis and vascularization through regulating many kinds of cellular effector molecules, and plays an important role in the process of tumor invasion and metastasis.