| 肝细胞生长因子及其受体与胃癌 |
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| 引用本文： | 陈俊忠,徐嘉凤,叶红军. 肝细胞生长因子及其受体与胃癌[J]. 国际消化病杂志, 2006, 26(2): 104-106 |
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| 作者姓名： | 陈俊忠 徐嘉凤 叶红军 |
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| 作者单位： | 深圳市龙岗中心医院消化内科,518116;北京大学深圳医院消化科,518036 |
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| 摘 要： | 肝细胞生长因子(HGF)是一种多功能的细胞因子,原癌基因c-met编码的蛋白c-Met是HGF的主要受体,HGF与上皮或内皮细胞上的c-Met结合,导致细胞分裂或分化增加,细胞分离,运动能力增强,细胞连接消失。近年研究表明,HGF可影响肿瘤的生长、侵袭和肿瘤新生血管形成,HGF/c-Met与胃癌的发生、发展、转移及预后有着密切的关系。
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| 关 键 词： | 肝细胞生长因子 受体 胃癌 |
| 收稿时间： | 2005-01-25 |
| 修稿时间： | 2005-01-25 |
Hepatocyte growth factor and its receptor (c-Met) in gastric cancer |
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| CHEN Jun-zhong,XU Jia-feng,YE Hong-jun. Hepatocyte growth factor and its receptor (c-Met) in gastric cancer[J]. International Journal of Digestive Disease, 2006, 26(2): 104-106 |
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| Authors: | CHEN Jun-zhong XU Jia-feng YE Hong-jun |
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| Abstract: | Hepatocyte growth factor (HGF) is a multifunctional cytokine. The c-Met protein of protooncogene c-met coding is the main receptor of HGF. HGF combines with the c-Met of epithelial or endothelial cells, leading to the increase of cell divide or differentiation, cell separation, increase of moving ability and extinction of cell junction. In recent years, the study has indicated that HGF can affect growth and aggression of tumor and formation of newborn blood vessels of tumor. There is consanguineous relation between HGF/c-Met with occurrence, development, metastasis and prognosis of gastric cancer. |
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| Keywords: | Hepatocyte growth factor Receptor (c-Met) Gastric cancer |
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