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Occupational Hypersensitivity Pneumonitis in a Japanese Citrus Farmer |
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| Authors: | Naokata Kutsuzawa Takahisa Takihara Yoshiki Shiraishi Hiroshi Kajiwara Tadashi Imanishi Yuma Fukutomi Katsuhiko Kamei Mari Takahashi Keito Enokida Yukihiro Horio Yoko Ito Naoki Hayama Tsuyoshi Oguma Koichiro Asano |
| Affiliation: | 1.Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan; 2.Department of Pathology, Tokai University School of Medicine, Japan; 3.Department of Molecular Life Science, Tokai University School of Medicine, Japan; 4.Clinical Research Center, National Hospital Organization Sagamihara National Hospital, Japan; 5.Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan |
| Abstract: | Hypersensitivity pneumonitis (HP) sometimes develops in people working in specific environments. We herein report a case of occupation-related HP in a citrus farmer in Japan. A 66-year-old man developed a fever, dyspnea, and general malaise in March after working near a trash dump filled with moldy tangerines. He presented with leukocytosis, bilateral lung opacities on chest radiographs, and intra-alveolar and interstitial lymphocytic inflammation with fibrotic change on a lung biopsy. His symptoms disappeared after admission and recurred on a revisit to the workplace. Fungal culture and a mycobiome analysis using next-generation sequencing suggested an association with exposure to Penicillium digitatum. |
| Keywords: | fungi hypersensitivity pneumonitis next generation sequencing occupational hypersensitivity pneumonitis Penicillium digtatum |