我院2006-2009年抗微生物药物应用分析

目的：分析我院2006-2009年抗微生物药物应用现状及其变化趋势,为临床合理用药提供参考。方法：采用用药金额排序法和限定日剂量法对我院2006-2009年抗微生物药物的用药金额、用药频度、日均费用等进行分析。结果：2006-2009年,我院抗微生物药物使用金额逐年上升,头孢菌素类稳居首位,青霉素类、抗真菌类及氨基糖苷类上升速度较快,年均增长率分别为128.11%,67.29%及50.67%;抗微生物药物用药金额排名前10位均为注射剂型,硫酸依替米星氯化钠连续四年位居前10位,抗真菌药醋酸卡泊芬净用量逐年上升,提示院内真菌感染增加;前10位药品日均费用偏高;氟氧头孢、头孢哌酮他唑巴坦（1g）、硫酸依替米星氯化钠、奥硝唑氯化钠及头孢孟多（1g）同步性较差。结论：2006-2009年,我院抗微生物药物的使用日趋合理,可能与2008年《解放军总医院抗菌药物管理规定》的实施有关,应加大对合理使用抗微生物药物的管理及宣传。

Application analysis of antibiotics in our hospital during 2006-2009

Objective：To analyze and evaluate the rationality and the development trend of antibiotics usage in our hospital.Methods：Data of antibiotics used in our hospital during 2006-2009 were retrieved from the medication analytical system,and the sales amounts,DDDs and DDC of antibiotics were analyzed by using the method of defined daily dose（DDD）.Results：Consumption sum of antibiotics kept increasing from 2006 to 2009,and cephalosporins ranked the first among the antibiotics used in our hospital over the years.Penicillins,antifungal and aminoglycosides agents increased rapidly with the increasing rate of 128.11%,67.29% and 50.67% respectively;the top 10 antibiotic drugs in terms of consumption sum were used by injection,and etimicin sulfate sodium chloride ranked the top 10 from 2006 to 2009;consumption of caspofungin acetate increased year by year,which reflected that mycotic infection in the hospital increased;the synchronicity of flomoxef,cefoperazone/tazobactam（1 g）,etimicin sulfate sodium chloride,ornidazole sodium chloride,and cefamandole（1 g） were poor.Conclusion：Application of antibiotics in our hospital during 2006-2009 was basically reasonable after the rules of the antimicrobial management were carried out in our hospital in 2008,and management and propaganda of antibiotics should be further strengthened.