心肌梗死患者及同胞血脂异常ApoE基因多态性分析

目的　评估心肌梗死(MI)患者及其同胞的冠心病易患因素及血脂异常相关基因ApoE的多态性。方法　对65例确诊为MI的男性患者、141例同性别健康同胞及47例年龄、性别相匹配的健康人进行流行病学问卷调查及临床检查，并从分子遗传学角度进行血脂异常相关基因ApoE多态性的检测，探索其与MI血脂异常的关系。结果　（1）MI组与同胞组总胆固醇(TC)（分别为5.0mmol/L±1.8mmol/L、4.8mmol/L±1.4mmol/L）、甘油三酯(TG)（分别为2.2mmol/L±1.7mmol/L、1.97mmol/L±0.26mmol/L）、低密度脂蛋白胆固醇(LDL-C)、TC/HDL-C比值均显著高于对照组（3.5mmol/L±0.9mmol/L、1.1mmol/L±0.9mmol/L)，其中MI组BMI、LDL-C、TC/HDL-C比值明显高于同胞组；（2）BMI>25kg/m

Dyslipidemia-related risk factors for myocardial infarction and polymorphism of ApoE gene among myocardial infarction patients and their siblings

Objective　To assess the risk factors of myocardial infarction (MI) and the polymorphism of the gene Apoliprotein (ApoE) genotype among MI patients and their siblings. Methods　Questionnaire survey and clinical examination were conducted to 65 male MI patients, 141 “healthy” male siblings of the MI patients, and 47 healthy persons matched in age and sex. Results　(1) The medians of TC, TG, LDL-C, TC/HDL-C in MI group and sibling group were higher than those in the control group with statistical significance. (2) BMI > 25 kg/m2, cigarette > 10 /d, TC > 5.2 mmol/L, TG > 2.26 mmol/L, LDL-C > 3.4 mmol/L,TC/HDL-C > 5.0, and FBG > 5.6 mmol/L were risk factors for MI; and HDL-C > 0.9 mmol/L was a protective factor for MI. (3) Among the three genotypes of ApoE, E3/3 was the commonest one. However, no significant difference was found in the distribution frequencies of these 3 genotypes, levels of serum lipid and lipoprotein, and TC/HDL-C. (4) Among the MI patients the number of allele E4 carrier was nearly twice the number of the non-allele E4 carrier. Conclusion　Dyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically.