乳腺癌患者血清微量元素测定的临床价值

目的:探讨9种血清微量元素与乳腺癌的关系。方法:采用原子吸收分光光谱法对61例健康妇女、78例乳腺癌手术前及61例乳腺癌手术后血清中铜(Cu)、铁(Fe)、锌(Zn)、锰(Mn)、铅(Pb)、铬(Cr)、镉(Cd)、镍(Ni)、钼(Mo)9种微量元素的含量进行测定。结果:3组血清中的微量元素含量有显著差异,其中血清Fe、Cu、Zn、Mn含量乳癌组明显高于健康对照组,血清Fe、Zn、Cu、Ni含量乳腺癌术前组明显高于乳腺癌术后组(P<0.01),血清Cu/Zn比值乳腺癌组高于健康对照组。结论:结果提示Fe、Zn、Cu、Mn、Ni可能是乳癌的危险因素,Mo可能为乳癌的保护因素。

Clinical Value of Determination of Trace Elements in Serum in Breast Cancer

Objective:To study the relation between trace elements in serum and breast cancer.Methods:In 61 healthy women and 61 patients with breast cancer,the levels of nine trace elements including Cu,Fe,Zn,Mn,Pb,Cr,Cd,Ni and Mo were determined.Results:There was significant difference in the levels of trace elements among groups.Compared with control group,the levels of Fe,Cu,Zn,Mn and Cu/Zn was higher in breast cancer group.The levels of Fe,Zn,Cu and Ni in preoperation group was higher than those in postoperation group(P<0.01).Conclusion:The results indicate that Fe,Zn,Cu,Mn and Ni may be risk factors of breast cancer,Mo may be prective factor of breast cancer.