| 胆囊癌C-erbB-2、EGFR、P21蛋白共同表达与PCNA的关系 |
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| 引用本文： | 姚钰,金玉湘,陈建熙,游志新. 胆囊癌C-erbB-2、EGFR、P21蛋白共同表达与PCNA的关系[J]. 肝胆胰外科杂志, 2003, 15(2): 100-102 |
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| 作者姓名： | 姚钰 金玉湘 陈建熙 游志新 |
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| 作者单位： | 温州市第二人民医院,病理科,浙江,温州,325000 |
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| 摘 要： | 目的 :探讨癌基因蛋白C erbB 2 (C erbB 2oncoproteins,C erbB 2 )、表皮生长因子受体 (epidermalgrowthfactorreceptor,EGFR)、ras癌基因产物P2 1(rasoncogenicprotein 2 1,P2 1)共同表达对胆囊癌细胞增殖的影响。方法 :应用免疫组化SP法对 5 1例胆囊癌组织标本进行了C erbB 2、EGFR、P2 1蛋白的测定 ,同时进行了增殖细胞核抗原 (proliferationcellnuclearantigen ,PCNA)的测定。结果 :3种癌基因蛋白全部阳性及C erbB 2和EGFR同时阳性的胆囊癌细胞PCNA指数高于 3种蛋白全部阴性组 (P <0 .0 5 )。结论 :C erbB 2、EGFR和P2 1蛋白共同表达及C erbB 2和EGFR共同表达可能对胆囊癌细胞增殖有协同作用
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| 关 键 词： | 胆囊肿瘤 免疫组织化学 癌基因蛋白 表皮生长因子受体 增殖细胞核抗原 |
| 文章编号： | 1007-1954(2003)02-0100-03 |
| 修稿时间： | 2003-04-23 |
Study on PCNA and co-expression of C-erbB-2,EGFR and P21 protein in gallbladder carcinoma |
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| YAO Yu,JIN Yu xiang,CHEN Jian xi,et al.. Study on PCNA and co-expression of C-erbB-2,EGFR and P21 protein in gallbladder carcinoma[J]. Journal of Hepatopancreatobiliary Surgery, 2003, 15(2): 100-102 |
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| Authors: | YAO Yu JIN Yu xiang CHEN Jian xi et al. |
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| Affiliation: | YAO Yu,JIN Yu xiang,CHEN Jian xi,et al. Department of pathology,the Second People's Hospital of Wenzhou,Wenzhou 325000 |
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| Abstract: | Objective:To study the influence between co expression of C erbB 2,EGFR and P21 protein in gallbladder carcinoma on the proliferation of the tumor cell.Methods:The expression of C erbB 2,EGFR,P21 protein and PCNA in tissues of 51 gallbladder carcinoma were studied by SP method.Results:The index of PCNA in carcinoma of the co expression of C erbB 2,EGFR and P21 protein,the co expression of C erbB 2 and EGFR was higher than that in those without any expression(P<0.05).Conclusion:There are high rate of tumor cell proliferation in the co expression of C erbB 2,EGFR and P21 protein and the co expression of C erbB 2 and EGFR. |
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| Keywords: | gallbladder tumor immunohistochemistry C erbB 2 EGFR P21 protein PCNA |
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