奥美拉唑对利培酮血药浓度影响的研究

目的：研究奥美拉唑对利培酮和9-羟利培酮血药浓度的影响.方法：采用自身对照法,对20例精神分裂症伴胃溃疡患者,在利培酮治疗基础上合用奥美拉唑（20 mg·d-1）治疗1周.用高效液相色谱法（HPLC）测定奥美拉唑合用前后利培酮及9-羟利培酮稳态血药浓度进行对比.结果：合用奥美拉唑前与合用1周末后利培酮和9-羟利培酮的血药浓度分别为（29.26±7.84）μg·L-1和（37.17±11.7）μg·L-1,差异有统计学意义（P＜0.05）.结论：奥美拉唑合用利培酮治疗,可使利培酮和9-羟利培酮的血药浓度升高.临床上合用奥美拉唑和利培酮治疗精神分裂症伴胃溃疡患者时,应监控利培酮和9-羟利培酮的血药浓度,调整用药剂量.

Effect of Omeprazole on Plasma Concentration of Risperidone

Objective ： To explore the effect of proton pump inhibitor omeprazole on plasma concentration of risperidone and 9-OH- risperitone. Method： Using self-control study, totally 20 schizoaffective disorder patients with gastric ulcer received omerazole （20 mg· d- 1 ） combined with risperidone for 1 week. The plasma concentration of risperidone and 9-OH- risperidone was monitored by HPLC before and after the combination. Result ： The co-medication with omerazole could increase the plasma levels of risperidone and 9-OH- risperitone from （29.26 ±7.84）μg · L-1 before the combination to （37.17 ± 11.7） μg · L-1 with significant difference （P 〈0.05）. Conclusion： Omeprazole can increase the plasma concentration of risperidone and 9-OH-rispridone, and close plasma concentration monitoring of risperidone and 9-OH-risperitone should be recommended. If the plasma concentration of risperidone and 9-OH-risper- itone is improved, the drug dosage should be adjusted accordingly.