艾司西酞普兰治疗老年抑郁症临床观察

目的：观察艾司西酞普兰对老年抑郁症患者的临床疗效和安全性.方法：60例老年抑郁障碍患者随机分为两组各30例,观察组应用草酸艾司西酞普兰片（5～10 mg·d-1）治疗8周;对照组给予舍曲林片（50～100 mg·d-1）治疗8周.采取汉密尔顿抑郁量表（HAMD）评定治疗前及治疗后2,4,6,8周的疗效,并观察药品不良反应.结果：观察组显效率为73.3%,有效率为93.3%,对照组显效率为56.7%,有效率为86.7%,两组差异无统计学意义（P＞0.05）,但治疗第2,4周时观察组的HAMD评分降低幅度明显高于对照组（P＜0.05）.观察组与对照组不良反应发生率分别为26.7%和36.7%,差异无统计学意义（P＞0.05）.结论：艾司西酞普兰治疗老年抑郁患者疗效显著,安全性较高.

Clinical Observation of Escitalopram in the Treatment of Senile Depression

Objective： To evaluate the efficacy and safety of escitalopram in the treatment of senile depression. Methods： A total of 60 patients with senile depression were randomly divided into two groups with 30 cases in each treated with escitalopram oxalate tab- lets 5-10 mg · d- 1 or sertraline hydrochloride tablets 50-100 mg ·d-1. The treatment duration was 8w. The efficacy of the drugs was evaluated by Hamilton Depression Rating Scale before the treatment and 2, 4, 6 and 8 w after the treatment, and the adverse drug re- actions was studied as well. Results： In escitalopram group and sertraline group, the obvious effective rate was respectively 73.3% and 56.7% , the efficiency rate was 93.3% and 86.7% , respectively with no significant difference （ P 〉 0.05 ） , however, at the end of 2 and 4 w in the treatment, more significant reduction in HAMA total scores in escitalopram group than that in sertralin group （ P 〈 0.05 ）. TESS Scale showed there was no statistically significant difference in the incidence of adverse reactions between escitalopram group （26.7%） and sertralin group （36.7%）. Conclusion： Escitalopram is effective and safe in the treatment of patients with senile depression.