Hemophagocytosis by Leukemic Megakaryoblasts in Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)(p13;q13);RBM15-MKL1 |
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Authors: | Wiseman Daniel H Bonney Denise K Wynn Robert F |
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Institution: | Department of Haematology & Oncology, Royal Manchester Children's Hospital, Manchester, UK. |
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Abstract: | Acute megakaryoblastic leukemia is a rare variant of acute myeloid leukemia, whereby leukemic blasts display characteristic morphologic and phenotypic features indicating megakaryocytoid differentiation. A distinct entity characterized by the t(1;22)(p13;q13) translocation, resulting in the RBM15-MKL1 fusion oncogene, has been recently recognized. This is predominantly a disease afflicting infants and displays characteristic clinical features. We present a case of acute megakaryoblastic leukemia with t(1;22)(p13;q13) along with a discussion of the current understanding of the molecular biology of RBM15-MKL1. This case also displayed striking and unusual morphologic appearances including extensive hemophagocytosis by leukemic blasts, which has not been previously reported for this particular type of leukemia. |
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