动脉弹性功能与非心源性脑梗死复发的相关性研究

目的 了解高原地区（海拔2230 m）动脉弹性功能（大动脉弹性指数C1，小动脉弹性指数C2）与非心源性脑梗死复发的关系及临床意义。方法 采用美国HDI-DO-2020动脉测试仪测定了342例脑梗死患者动脉弹性功能，并对该组脑梗死患者进行了12月的临床随访，观察其动脉弹性功能与脑梗死复发的关系。结果 高原地区动脉粥样硬化性脑梗死的复发率低于腔隙性脑梗死（17.17% vs 22.6%， P＜0.05）；小动脉弹性指数C2在腔隙性脑梗死患者中明显降低（P＜0.05）；而复发腔隙性脑梗死患者C2降低的更明显。Logistic回归分析发现，小动脉弹性指数C2与腔隙性脑梗死复发有密切关系。结论 高原地区小动脉弹性指数C2与非心源性腔隙性脑梗死复发有密切关系。临床上常规检测C2变化对高原地区预测和防治脑梗死复发具有一定的指导意义。

Relationship between Arterial Elasticity and Recurrence of Non-cardiogenic Cerebral Infarction in Plateau

Objective To study the relationship between arterial elasticity(large artery elasticity index C1 and small artery elasticity index C2)and recurrence of non-cardiogenic cerebral infarction in plateau(2230 m).Methods Arterial elasticity of 342 patients with cerebral infarction were evaluated by HDI DO-2020 in plateau(2230 m).All the patients were followed for 12 months,and recurring prevalence of cerebral infarction was registered.Then we analyzed the relationship between cerebral infarction recurrence and arterial elasticity.Results In plateau recurring prevalence of cerebral infarction was 17.17%,but of lacunar infarction was 22.6%,significantly higher than cerebral infarction(P<0.05).Significantly decreased C2 was found in lacunar infarction(P<0.05),but the decrease was more obviously in recurring lacunar infarction(P<0.05).Logistic analysis showed there was correlation between C2 and recurring prevalence of lacunar infarction.Conclusion There is correlation between arterial elasticity and recurrence of non-cardiogenic lacunar infarction in plateau.Examination of C2 may be helpful to prevent and treat recurrence of cerebral infarction.