| 抗坏血酸在注射液中的降解途径 |
| |
| 引用本文： | 何平,殷恭宽. 抗坏血酸在注射液中的降解途径[J]. 药学学报, 1986, 0(9) |
| |
| 作者姓名： | 何平 殷恭宽 |
| |
| 作者单位： | 华西医科大学药学系 成都(何平)，华西医科大学药学系 成都(殷恭宽) |
| |
| 摘 要： | 研究了中性抗坏血酸注射液在无氧条件下的降解产物和降解反应。检测出的降解产物有;2-酮-L-古洛糖酸、二氧化碳和木糖,分离、鉴定了新的降解产物——丙酮醛,并研究了抗坏血酸的水解与2-酮-L-古洛糖酸脱羧的反应动力学,提出了中性抗坏血酸注射液在无氧条件下可能的降解途径。
|
| 关 键 词： | 抗坏血酸 无氧降解 2-酮-L-古洛糖酸 丙酮醛 |
THEPATHWAY FOR THE ANAEROBIC DEGRADATION OF ASCORBIC ACID IN NEUTRAL INJECTION |
| |
| HE Ping and YIN Gong-Kuan. THEPATHWAY FOR THE ANAEROBIC DEGRADATION OF ASCORBIC ACID IN NEUTRAL INJECTION[J]. Acta pharmaceutica Sinica, 1986, 0(9) |
| |
| Authors: | HE Ping and YIN Gong-Kuan |
| |
| Abstract: | The anaerobic degradation of ascorbic acid in neutral injection has been studied. Some degradation products as 2-keto-L-gulonic acid and xylose were identified by using of TLC. A new degradation product pyruvaldehyde was isolated and identified as 2,4-dinitrophenylhydrazone. The amount, of 2-keto-L-gulonic acid formed from degradation of ascorbic acid in injection and amount of carbon dioxide produced from that of ascorbic acid and 2-keto-L-gulonic acid were determined. From these, the pathway for the anaerobic degradation of ascorbic acid in neutral injection Was proposed. |
| |
| Keywords: | Ascorbic acid Anaerobic degradation Degradation pathway 2-keto-L-gulonic acid Pyruvaldehyde |
| 本文献已被 CNKI 等数据库收录！ |
