A case of MELAS syndrome with typical cluster headache attacks: is it a causel or coincidental association? |
| |
Authors: | Brune M Fusco Mario Giacovazzo |
| |
Institution: | (1) Department of Pharmaceutical Science, Univesity of Salermo, Via del Ponte Don Melillo, I-84084 Fsciano (SA), Italy, e-mail: fuscobr@unisa.it, Tel.: +39-089-962726, IT;(2) Institute of Internal Medicine, Second Faculty of Medicine, La Sapienza University of Rome, Rome, Italy, IT |
| |
Abstract: | Many findings relate migraine and cluster headaches to a genetic alteration, even if the site of the defect has not been
identified. Some of these findings indicate an involvement of mitochondrial DNA, although some contrasting results have been
reported. We describe a case of cluster headache occuring in a patient with MELAS syndrome. The diagnosis of MELAS was supported
by the familiar anamnesis (the mother suffered from a similar form), by the laboratory reports (lacto-acidosis), by instrumental
analysis (signs of encephalopathy on magnetic resonance imaging) and by biopsy findings (myopathy). The diagnosis was confirmed
when a point mutation (Leu mutation at position 3423 of mitochondrial RNA) was found in the mitochondrial gene. The recurrent
periods, characterized by attacks of unilateral pain and accompanied by homolateral symptoms (e. g. tearing, palpebral ptosis,
rhinorrea), did not leave any doubt as to the diagnosis of cluster headache. We discuss whether the co-existence of MELAS
and cluster headache was coincidental or causal.
Received: 7 June 2001 / Accepted in revised form: 4 December 2001 |
| |
Keywords: | Cluster headache mtDNA Lacto-acidosis MELAS Mitochondrial disease |
本文献已被 SpringerLink 等数据库收录! |
|