Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels |
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Authors: | Chatzikyriakidou Anthoula Vakalis Konstantinos V Kolaitis Nicholas Kolios Georgios Naka Katerina K Michalis Lampros K Georgiou Ioannis |
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Affiliation: | Department of Obstetrics and Gynecology, Ioannina University School of Medicine, Ioannina, 45110, Greece. |
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Abstract: | OBJECTIVES: The role of SLC19A1 -43T>C, MTHFR 677C>T and MS 2756A>G polymorphisms on red cell and plasma folate levels. DESIGN AND METHODS: Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease. RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels. CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels. |
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Keywords: | Red cell folate Plasma folate Gene polymorphisms MTHFR SLC19A1 |
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