The impact of medical comorbidity on acute treatment in major depressive disorder |
| |
| Authors: | Iosifescu Dan V Nierenberg Andrew A Alpert Jonathan E Smith Megan Bitran Stella Dording Christina Fava Maurizio |
| |
| Affiliation: | Depression Clinical and Research Program, Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. diosifescu@partners.org |
| |
| Abstract: | OBJECTIVE: The authors investigated the impact of medical comorbidity on the acute phase of antidepressant treatment in subjects with major depressive disorder. METHOD: A total of 384 outpatients meeting DSM-III-R criteria for major depressive disorder enrolled in 8-week open treatment with fluoxetine, 20 mg/day. The authors used the Cumulative Illness Rating Scale to measure the burden of medical comorbidity and the 17-item Hamilton Rating Scale for Depression to assess changes in depressive symptoms. The outcome measures were response to treatment (>/=50% reduction in score) and clinical remission (score
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
