| UPLC/MS/MS法检测补肾壮阳类中成药中非法添加枸橼酸西地那非的定性定量研究 |
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| 引用本文： | 张翠英,李振国,徐金铃,蔡少青. UPLC/MS/MS法检测补肾壮阳类中成药中非法添加枸橼酸西地那非的定性定量研究[J]. 中国卫生检验杂志, 2007, 17(10): 1741-1742,1812 |
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| 作者姓名： | 张翠英 李振国 徐金铃 蔡少青 |
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| 作者单位： | 1. 河南省食品药品检验所,郑州,450003
2. 北京大学药学院,北京,100083 |
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| 摘 要： | 目的:建立快速、准确、高灵敏度的中成药中非法添加西地那非的检测方法。方法:采用超高效液相色谱-质谱联用法,离子源为ESI源,正、负离子同时检测,对中成药中非法添加的枸橼酸西地那非进行定性和定量检测。结果:21种受试制剂中3种检测到掺有枸橼酸西地那非。结论:此方法选择性强、灵敏度高,可作为分析中成药中非法添加枸橼酸西地那非的有效检测方法。
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| 关 键 词： | 超高效液相色谱-质谱-质谱联用法 枸橼酸西地那非 定性分析 定量测定 多反应监测 |
| 文章编号： | 1004-8685（2007）10-1740-03 |
| 收稿时间： | 2007-06-26 |
| 修稿时间： | 2007-06-26 |
Qualitative and quantitative analysis of sildenafil citrate illegally mixed into traditional chinese medicinal preparation for invigorant by UPLC/MS/MS |
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| Zhang Cui-ying,Li Zhen-guo,Xu Jin-ling,Cai Shao-qing. Qualitative and quantitative analysis of sildenafil citrate illegally mixed into traditional chinese medicinal preparation for invigorant by UPLC/MS/MS[J]. Chinses Journal of Health Laboratory Technology, 2007, 17(10): 1741-1742,1812 |
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| Authors: | Zhang Cui-ying Li Zhen-guo Xu Jin-ling Cai Shao-qing |
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| Affiliation: | 1. Henan Institute for Food and Drug Control, Zhengzhou 450003, China; 2. Pharmaceutical School, Peking University, Beijing 100083, China |
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| Abstract: | Objective:To establish a quick,accurate,sensitive method for analysis of sildenafil citrate illegally added into traditional chinese medicinal preparation for invigorant by UPLC-MS-MS.Methods:The UPLC-MS-MS method was used.Electrospay ionization(ESI) source was applied and operated in both positive and negative ion modes.The qualitative and quantitative method of sildenafil citrate illegally added into traditional chinese medicinal preparations for invigorant were carried out.Results:Sildenafil citrate was found in three formulations of twenty-one.Conclusion:The method is selective and sensitive and can be used to detect the sildenafil citrate illegally added into traditional chinese medicinal preparations for invigorant. |
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| Keywords: | Ultra performance liquid chromatography-MS-MS(UPLC-MS-MS) Sildenafil citrate Qualitative analysis Quantitative analysis MRM |
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