卒中后抑郁的相关因素分析

目的探讨卒中后抑郁(PSD)的相关因素。方法采用汉密尔顿抑郁量表(HAMD)在卒中后14 d及90 d对300例脑卒中患者进行评分,并据此分为PSD组及非PSD组,对两组间的卒中部位、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表评分(mRS)及简易精神状态检查表(MMSE)评分进行比较。结果 140例(46.7%)患者发生PSD;卒中灶多发或位于左侧半球、额颞叶及基底节的患者PSD发生率明显高于卒中灶单发、位于右侧半球、顶枕叶及皮质的患者(均P<0.05);PSD组发病14 d时NIHSS评分、发病14 d及90 d时mRS评分明显高于非PSD组(P<0.05～0.01)。结论 PSD发生与多灶性卒中及卒中灶位于左侧半球、额颞叶、基底节区有关;且与卒中后神经功能缺损程度及残疾程度有关。

Related factors analysis of post-stroke depression

Objective To explore the related factors of post-stroke depression(PSD).Methods According to the scores of Hamilton Depression Scale(HAMD) assessed at 14 d and 90 d after stroke,the 300 stroke patients were divided into PSD group and non-PSD group.The lesion location,the scores of National Institute of Health stroke scale(NIHSS),modified rainkin Scale(mRS) and minimental status examination(MMSE) were compared between the two groups.Results There were 140 cases(46.7%) with PSD.The incidences of PSD in patients with multiple infarct lesions and the lesions located at left hemisphere,fronto-temporal lobe and basal ganglia were significant higher than the patients with single infarct lesion,and the lesion located at right hemisphere,parietal-occipital lobe and cortex(allP<0.05).The NIHSS score at 14 d after onset,and mRS scores at 14 d,90 d after onset in PSD group were significant higher than thos in non-PSD group(P<0.05-0.01).Conclusion The PSD occurrence is correlated with the multifocal stroke and stroke located at left hemisphere,fronto-temporal lobe and basal ganglia;also with degrees of neurological function deficit and disability.