妈富隆与二甲双胍联合预处理对多囊卵巢综合征不孕的疗效

目的观察多囊卵巢综合征(PCOS)合并不孕患者采用妈富隆及二甲双胍联合预处理的临床疗效。方法将符合PCOS诊断的不孕患者264例分为两组:A组,136例,共计210个周期,采用口服妈富隆、二甲双胍联合预处理,再用克罗米芬(CC)+人尿促性腺激素(HMG)促排卵方案治疗;B组,128例,共计194个周期,直接用CC+HMG促排卵方案治疗。比较两组用药前后血清黄体生成素(LH)、LH/促卵泡素(FSH)、睾酮(T)、空腹胰岛素(FIns)的变化,以及周期排卵率和妊娠率。结果两组治疗后血清LH、LH/FSH、T、FIns均见下降,但A组各指标的下降程度显著大于B组(P<0.05)。A组周期排卵率显著高于B组(83%vs.37%)(P<0.05),A组周期妊娠率显著高于B组(45%vs.11%)(P<0.05)。结论采用妈富隆及二甲双胍联合预处理治疗PCOS不孕,可更有效地改善胰岛素抵抗,降低血清LH、LH/FSH、T水平,并且提高PCOS不孕患者的排卵率及妊娠率。

Efficacy of pretreatment with combined use of mawelon and metformin in patients with PCOS-related infertility

Objective To investigate the efficacy of pretreatment with combined use of mawelon and metformin in patients with polycystic ovarian syndrom(PCOS)-related infertility. Methods The patients with PCOS-related infertility were divided into two groups of A(136 cases,210 cycles,treated with combined mawelon and metformin pretreatment and followed by CC and HMG for induction of ovulation) and B(128 cases and 194 cycles,treated with CC and HMG for induction of ovulation directly).Serum levels of LH,LH/FSH,T and fasting insulin(Fins) and the rates of induction of ovulation and pregnancy were compared between two groups. Results The levels of LH, LH/FSH,T and FIns of two groups decreased significantly after treatment,which was more in group A than that in group B(P<0.05).The rate of induction of ovulation in group A was more than that in group B(83% vs.37%)(P<0.05).Pregnant rate in group A was more than that in group B(45% vs.11%)(P<0.05). Conclusion Combined pretreatment with mawelon and metformin on PCOS patients of infertility can reduce more effectively the insulin resistance,decrease serum levels of LH,LH/FSH and T and improve the rate of induction of ovulation and pregnancy.