Creutzfeldt-Jakob病的临床和影像学特点 |
| |
引用本文: | 孙光林,许利刚,刘晨,李作汉. Creutzfeldt-Jakob病的临床和影像学特点[J]. 临床神经病学杂志, 2012, 25(1): 14-16 |
| |
作者姓名: | 孙光林 许利刚 刘晨 李作汉 |
| |
作者单位: | 1. 211308,江苏省高淳监狱医院 2. 南京脑科医院神经内科 |
| |
摘 要: | 目的探讨Creutzfeldt-Jakob病(CJD)的临床及影像学特征。方法回顾性分析29例CJD患者的临床资料。结果本组有12例CJD患者以快速进展性痴呆起病;典型的临床表现为进行性痴呆(100%)、共济失调(93.1%)、肌阵挛(89.6%)。EEG均异常,出现典型三相波17例、不典型三相波8例。头颅MRI表现双侧皮质高信号或基底节区T2WI对称性高信号15例,单侧皮质高信号6例,单侧基底节区高信号4例;20例行MR弥散加权成像(DWI)扫描,双侧皮质或基底节区出现高信号14例,一侧皮质或基底节区高信号各3例。14例双侧DWI高信号的患者均出现EEG典型三相波。3例行脑脊液14-3-3蛋白检查,2例阳性。结论 CJD患者多以快速进展性认知功能障碍起病,典型的临床表现为痴呆、共济失调、肌阵挛;EEG、DWI、CSF 14-3-3检测是诊断CJD的重要检查手段;DWI双侧皮质及基底节高信号可能与EEG出现三相波有关。
|
关 键 词: | Creutzfeldt-Jakob病 临床特点 MRI |
Clinical and imaging features of Creutzfeldt-Jakob disease |
| |
Affiliation: | SUN Guang-lin,XU Li-gang,LIU Chen,et al.Department of Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
| |
Abstract: | Objective To investigate the clinical and imaging features of Creutzfeldt-Jakob disease(CJD).Methods The clinical data of 29 CJD patients were analyzed retrospectively.Results In this group,12 cases were onset by rapid progressed dementia.The typical clinical manifestation were progressive dementia(100%),incoordination(93.1%),myoclonia(89.6%).EEG was abnormal in all the patients,17 cases appeared typical triphasic wave and 8 cases appeared atypical triphasic wave.On MRI T2WI,the symmetry high signal was observed in bilateral cortex or basal ganglia in 15 cases,in unilateral cortex in 6 cases and in singel basal ganglia in 4 cases.Twenty cases carried out MRI diffusion weighted images(DWI),the high signal in bilateral cortex or basal ganglia was observed in 14 cases,and in unilateral cortex or singal in basal ganglia was 3 cases respectively.Fourteen cases with high signal in bilateral cortex or basal ganglia on MRI DWI appeared the typical triphasic wave on EEG.The level of CSF 14-3-3 protein was detecled in 3 cases,and 2 cases showed positive.Conclusions Most CJD patients onset with rapidly progressive dementia.The typical clinical features are dementia,incoordination and myoclonia.EEG,DWI and CSF 14-3-3 protein test are the major methods of examination for diagnosis of CJD.High signal in bilateral cortex or basal ganglia in DWI may be related to typical triphasic wave on EEG. |
| |
Keywords: | Creutzfeldt-Jakob disease clinical features MRI |
本文献已被 CNKI 万方数据 等数据库收录! |
|