酒石酸长春瑞滨长循环热敏脂质体的荷瘤小鼠药效学研究 |
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引用本文: | 王幸平,王志媛,龚伟,梅兴国.酒石酸长春瑞滨长循环热敏脂质体的荷瘤小鼠药效学研究[J].军事医学,2012,36(5):362-364. |
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作者姓名: | 王幸平 王志媛 龚伟 梅兴国 |
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作者单位: | 王幸平 (武汉工程大学化工与制药学院,武汉,430073) ; 王志媛 (军事医学科学院毒物药物研究所,北京,100850) ; 龚伟 (军事医学科学院毒物药物研究所,北京,100850) ; 梅兴国 (军事医学科学院毒物药物研究所,北京,100850) ; |
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基金项目: | 国家"十二五"重大专项资助项目 |
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摘 要: | 目的评价酒石酸长春瑞滨长循环热敏脂质体(V-LCTL)对荷瘤小鼠的药效和不良反应。方法建立荷Lewis肺癌小鼠皮下肿瘤模型,静脉注射药品,比较V-LCTL与酒石酸长春瑞滨注射液(V-I)、酒石酸长春瑞滨长循环脂质体(V-LCL)的抗肿瘤作用,包括肿瘤生长曲线,抑瘤率,考察给药频率及量效关系。结果各治疗组均有抑瘤作用。相同剂量下V-LCTL的抑瘤效果明显强于V-LCL和V-I。单次给药和多次给药对V-LCTL和V-I的抑瘤率无显著影响。单次给药时不良反应明显。V-LCTL的抑瘤效果呈剂量依赖性(低、中、高剂量组抑瘤率分别为54.6%,72.1%,81.5%)。结论 V-LCTL具有比V-I和V-LCL更好的抑瘤效果,多次给药不良反应小,且V-LCTL的抑瘤效果具有剂量依赖关系。
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关 键 词: | 酒石酸长春瑞滨 长循环热敏脂质体 药效学 抗肿瘤药 |
Pharmacodynamics of vinorelbine tartrate long-circulating thermosensitive liposomes in mice bearing Lewis lung carcinoma cells |
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Authors: | WANG Xing-ping WANG Zhi-yuan GONG Wei MEI Xing-guo |
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Institution: | 1.School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430073,China;2.Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China) |
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Abstract: | Objective To investigate the tumor inhibition effect and toxicity of vinorelbine tartrate long-circulating thermosensitive liposome(V-LCTL) in mice bearing Lewis lung carcinoma cells.Methods A model of tumor-bearing mice was established by subcutaneous injection of Lewis lung cancer cells.The drug solution was intravenously administered to compare the anti-tumor effect of V-LCTL,vinorelbine tartrate long-circulating liposome(V-LCL) and vinorelbine tartrate injection(V-I).The tumor growth curve was obtained and the tumor inhibitory rate was calculated.The frequency of administration and dose-effect relationship of V-LCTL were systematically investigated.Results Each administered group showed inhibition effect on the growth of tumor.The inhibition effect of V-LCTL was better than that of V-LCL group and V-I group,respectively.Two methods of administration showed no significant difference in the inhibition rate of V-LCTL and V-I,but the toxicity and side effect of mice treated by single administration of 30 mg/kg were increased.There was a dose-effect relationship in the treatment of V-LCTL(54.6%,72.1%,and 81.5% in its low,medium and higher dose subgroups).Conclusion The inhibitory efficiency of V-LCTL is better than that of V-I and V-LCL.Three-time administration of V-LCTL decreases the toxicity and side effect.The tumor inhibitory effect of V-LCTL is positively correlated with the dose. |
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Keywords: | vinorelbine tartrate long-circulating thermosensitive liposome pharmacodynamics antineoplastic agents |
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