首页 | 本学科首页   官方微博 | 高级检索  
     


Sclerotic bodies in nephrogenic systemic fibrosis: a new histopathologic finding
Authors:Jag Bhawan  Brian L. Swick  Amy B. Koff  and Mary S. Stone
Affiliation:Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA;,
Department of Dermatology and Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA;and
Cranberry Square Dermatology, South Dennis, MA, USA
Abstract:Nephrogenic systemic fibrosis (NSF – known previously as nephrogenic fibrosing dermopathy) is a systemic disorder observed exclusively in patients with a history of kidney disease associated with renal failure. Reported histopathologic findings of NSF include spindle-shaped fibroblast-like cells with fibrosis, thickened collagen bundles with surrounding spindled and epithelioid cells, increased number of elastic fibers, sparse inflammatory infiltrate and increased stromal mucin. Two populations of multinucleated giant cells (Factor XIIIa and CD68 positive) have also been observed. We observed the presence of sclerotic bodies with entrapped elastic fibers in two cases of NSF, which we interpreted to be collagenous in nature, a finding not previously reported. These bodies should not be confused with osseous metaplasia previously seen in association with NSF, which show lacunae and cells within the osseous bodies that may or may not be calcified. We did not observe lacunae or cells within the sclerotic bodies in our cases. Furthermore, the sclerotic bodies in our cases stained blue on Masson trichrome, whereas previous investigators observed the osseous metaplasia to be red. We suggest that sclerotic bodies may be an additional clue to the diagnosis of NSF.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号