血流动力与肺淋巴引流在肺水调节机制中的作用

目的：研究血流动力和肺淋巴引流对肺水的调节作用。方法：以扩容手段使山羊血流动力、肺淋巴引流和肺水发生改变，定时监测这些改变的参数并进行比较。结果：在各项血流动力参数中，外周血管阻力（SVR）的变化对肺水的影响最为显著。SVR下降不仅可以缓解体液向肺循环中转移，肺淋巴引流也有所增加。肺淋巴流出管全部结扎的动物，肺水肿的发生并不如预料之迅速，但SVR的下降却甚突出，可能即因此缓解了肺水的聚集。正常的血流动力虽是肺水的来源和运行动力，但其疏导肺水的作用却比较间接。肺淋巴液的疏导主要取决于肺血水重、总肺水量和血管外肺水的多寡，其他因素的影响并不显著。结论：肺水本身可能具有一定的（自身）调节能力。

A STUDY OF THE ROLE OF HEMODYNAMICS AND LYMPHATIC DRAINAGE IN THE REGULATION OF LUNG WATER

Objective: To investigate the influence of hemodynamics and lung lymphatic drainage on theregulation of lung water. Methods: By means of bodY fluid expansion, status of hemodynamics, lung lymphaticdrainage and lung water were altered. Data of these changes were recorded and statistically analyzed. Results:The decrease of SVR was an important factor not only in the lessening of the pooling of bodY fluid into thepulmonary circulation, but, also in enhancing lung lymphatic drainage. A significant lowering of SVR wastiggered by the occlusion of lung lymph outflow. Accordingly it is believed that the relationship between lunglymph outflow and SVR plays a role not to be ignored in the mechanism of lung water regulation. Althoughthe normal hemodruamics is essential for the formation and turnover of lung water, it appeared not so effectivein the enhancement of lung lymphatic drainage in our experiment. Lung lymphatic drainage depended chieflyon lung blood water content, on total lung water content and on extravascular lung water. Conclusion: lungwater itSelf is one of the regulating factors of lung water homeostasis.