幽门螺杆菌在牙菌斑中的分布研究

目的：为探讨幽门螺杆菌（ＨＰ）在口腔内的分布及感染方式，本实验对不同程度牙周炎患者４６例，对照组２０例进行了龈上及龈下菌斑研究。方法：采用ＰＣＲ技术，提取ＨＰ的染色体ＤＮＡ，对其特异性片段进行诊断。结果：牙周炎组ＨＰ阳性率平均３９．１％，健康对照组１５％，重症牙周炎组阳性率５２．３％，显示了ＨＰ在口腔分布与年龄、牙位、牙周炎的程度密切相关。结论：牙菌斑是ＨＰ孳生地，口腔环境可能是ＨＰ一条传播通道，有关ＨＰ对牙周组织损害的研究尚待深入。

Study the distribution ofhelicobacter pylori in dentalplaque by polymerase chain reaction

Aim:Whether the oral cavity is a potential reservoir and possible sanctuary for Helicobacter pylori, we investigated the distribution of helicobacter pylori and its infection in tooth plaque. Methods: Forty-six patients with periodontitis and twenty controls with healthy were studied in the supergingival and subgingival plaques by polymerase chain reaction. Results: 18 patients(39.1%) with periodontitis was identified in their plaque, controls was 15%; to severe periodontitis,the HP positive rate 52.3%; the distribution of HP had relation with age, sex, teeth site,activities of periodontitis. Conclusions: The detection of HP in dental plaques suggested that HP colonization is not restricted to the gastric mucous and this ecological niche may serve be as a possible sanctuary which may be responsible for resettle of the stomach HP. Complete treatment to periodontitis is very important to periodontal and stomach health.