Multiple myeloma involving the cavernous sinus: a report of 3 cases and response to bortezomib |
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Authors: | Gozzetti Alessandro Cerase Alfonso Tarantino Annachiara Fabbri Alberto Bocchia Monica Pirrotta Maria Teresa Lauria Francesco |
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Institution: | Division of Hematology and Transplants, Policlinico Santa Maria alle Scotte, University of Siena, Italy. gozzetti@unisi.it |
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Abstract: | Intracranial multiple myeloma is uncommon. Cavernous sinus involvement has rarely been reported, generally associated with treatment-refractory disease and poor outcome. We report clinical data and neuroradiologic findings of 3 patients with multiple myeloma and unilateral cavernous sinus involvement. At neuroradiology, this resulted from diffuse bone involvement as disease relapse (n=2) or focal dural disease (n=1) as the presenting sign. Interestingly, bortezomib treatment resulted in complete clinical resolution in 1 patient and partial clinical and significant magnetic resonance response in another, whereas in the literature, local radiation therapy has been reported as the only efficient treatment. |
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