外源性补充谷氨酰胺对急性肠道移植物抗宿主病的影响 |
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引用本文: | 李云龙,高蕾,张曦,孔佩艳,文钦,刘嘉. 外源性补充谷氨酰胺对急性肠道移植物抗宿主病的影响[J]. 西部医学, 2012, 24(11): 2096-2098 |
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作者姓名: | 李云龙 高蕾 张曦 孔佩艳 文钦 刘嘉 |
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作者单位: | 第三军医大学附属第二医院血液科·重庆市医学重点学科·全军白血病中心,重庆400037 |
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基金项目: | 重庆市医学重点学科,第三军医大学新桥医院"1130"人才工程培养基金资助 |
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摘 要: | 目的探讨外源性补充谷氨酰胺对急性肠道移植物抗宿主病(GVHD)治疗的影响。方法将22例急性肠道GVHD患者随机分为标准化全胃肠外营养组(标准组,n=8)和加用谷氨酞胺的全胃肠外营养组(谷氨酰胺组,n=14),在出现肠道GVHD的第1天开始给予全胃肠外营养。结果两组患者摄入的营养物质基本相同,谷氨酞胺组好转时间为16d(6~31d),巨细胞病毒感染4例(29%),标准组好转时间为19天(10~25d),发生6例(75%)肠道巨细胞病毒感染。结论外源性补充谷氨酞胺能缩短急性肠道移植物抗宿主病好转时间,减少巨细胞病毒感染,有利于急性肠道GVHD患者恢复。
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关 键 词: | 外源性 谷氨酰胺 急性肠道移植物抗宿主病 |
Effects of extrinsic glutamine on patients with intestinal-type acute graft versus host disease |
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Affiliation: | LI Yun-long,GAO Lei,ZHANG Xi,et al(Department of Hematology,Xinqiao Hospital,The Third Military Medical University,Chongqing 400037,China) |
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Abstract: | Objective To investigate the effects of extrinsic glutamine on patients with intestinal-type acute graft versus host disease(aGVHD). Methods 22 patients with intestinal-type aGVHD were randomly divided into the group of standard total parenteral nutrition(standard TPN, n= 8) and the group of standard TPN with Gln(Gln group,n = 14), Parenteral nutrition was initiated at the day after intestinal-type aGVHD (day 1). Results Nutrient intake was similar in both groups. The recovery time of Gln group was at 16 days(6-31d),four(29%)cases of CMV infection happened. The recovery time of standard TPN was at 19 days(10-25d) ,and six(75%)cases of CMV infection happened. Conclusion Extrinsic glutamine can shorten the recovery time on patients with intestinal-type aGVHD, diminishing the incidence of CMV. |
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Keywords: | Extrinsic Glutamine Intestinal-type aGVHD |
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