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外源性补充谷氨酰胺对急性肠道移植物抗宿主病的影响
引用本文:李云龙,高蕾,张曦,孔佩艳,文钦,刘嘉. 外源性补充谷氨酰胺对急性肠道移植物抗宿主病的影响[J]. 西部医学, 2012, 24(11): 2096-2098
作者姓名:李云龙  高蕾  张曦  孔佩艳  文钦  刘嘉
作者单位:第三军医大学附属第二医院血液科·重庆市医学重点学科·全军白血病中心,重庆400037
基金项目:重庆市医学重点学科,第三军医大学新桥医院"1130"人才工程培养基金资助
摘    要:目的探讨外源性补充谷氨酰胺对急性肠道移植物抗宿主病(GVHD)治疗的影响。方法将22例急性肠道GVHD患者随机分为标准化全胃肠外营养组(标准组,n=8)和加用谷氨酞胺的全胃肠外营养组(谷氨酰胺组,n=14),在出现肠道GVHD的第1天开始给予全胃肠外营养。结果两组患者摄入的营养物质基本相同,谷氨酞胺组好转时间为16d(6~31d),巨细胞病毒感染4例(29%),标准组好转时间为19天(10~25d),发生6例(75%)肠道巨细胞病毒感染。结论外源性补充谷氨酞胺能缩短急性肠道移植物抗宿主病好转时间,减少巨细胞病毒感染,有利于急性肠道GVHD患者恢复。

关 键 词:外源性  谷氨酰胺  急性肠道移植物抗宿主病

Effects of extrinsic glutamine on patients with intestinal-type acute graft versus host disease
Affiliation:LI Yun-long,GAO Lei,ZHANG Xi,et al(Department of Hematology,Xinqiao Hospital,The Third Military Medical University,Chongqing 400037,China)
Abstract:Objective To investigate the effects of extrinsic glutamine on patients with intestinal-type acute graft versus host disease(aGVHD). Methods 22 patients with intestinal-type aGVHD were randomly divided into the group of standard total parenteral nutrition(standard TPN, n= 8) and the group of standard TPN with Gln(Gln group,n = 14), Parenteral nutrition was initiated at the day after intestinal-type aGVHD (day 1). Results Nutrient intake was similar in both groups. The recovery time of Gln group was at 16 days(6-31d),four(29%)cases of CMV infection happened. The recovery time of standard TPN was at 19 days(10-25d) ,and six(75%)cases of CMV infection happened. Conclusion Extrinsic glutamine can shorten the recovery time on patients with intestinal-type aGVHD, diminishing the incidence of CMV.
Keywords:Extrinsic  Glutamine  Intestinal-type aGVHD
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