| 龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸和封闭度的影响 |
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| 引用本文： | 季宇彬,王胜惠,高世勇,邹翔,汲晨峰.龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸和封闭度的影响[J].中草药,2005,36(1):79-81. |
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| 作者姓名： | 季宇彬 王胜惠 高世勇 邹翔 汲晨峰 |
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| 作者单位： | 哈尔滨商业大学药物研究所,博士后科研工作站,黑龙江,哈尔滨,150076 |
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| 基金项目： | 国家自然科学基金资助项目(30400591)，黑龙江省自然科学基金资助项目(D2004-13)，哈尔滨市青年科学基金资助项目(2004AFQXJ035)。 |
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| 摘 要： | 目的研究龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸(SA)水平和封闭度的影响。方法建立H22荷瘤小鼠模型,荷瘤小鼠分别sc生理盐水、环磷酰胺、龙葵碱(9.375、18.75、37.5mg/kg)。采用比色法测定H22小鼠肿瘤细胞膜SA水平和封闭度。结果龙葵碱可剂量依赖性地降低荷瘤小鼠肿瘤细胞膜SA水平和肿瘤细胞膜封闭度。结论龙葵碱通过降低H22荷瘤小鼠肿瘤细胞膜SA水平和肿瘤细胞膜封闭度起抗肿瘤作用。
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| 关 键 词： | 龙葵碱 H荷瘤小鼠 膜封闭度 唾液酸 |
| 文章编号： | 0253-2670(2005)01-0079-03 |
| 收稿时间： | 5/2/2004 12:00:00 AM |
Effect of Solanum nigrum total alkaloid on sialic acid and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice |
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| JI Yu-bin,WANG Sheng-hui,GAO Shi-yong,ZOU Xiang and JI Chen-feng.Effect of Solanum nigrum total alkaloid on sialic acid and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice[J].Chinese Traditional and Herbal Drugs,2005,36(1):79-81. |
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| Authors: | JI Yu-bin WANG Sheng-hui GAO Shi-yong ZOU Xiang and JI Chen-feng |
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| Institution: | Postdoctoral Programme, Institute of Materia Medica, Harbin University of Commerce, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin University of Commerce, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin University of Commerce, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin University of Commerce, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin University of Commerce, Harbin 150076, China |
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| Abstract: | Objective To study the effects of total alkaloid from Solanum nigrum (TASN) on sialic acid (SA) and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice. Methods H_(22) tumor-bearing mice model was established and H_(22) tumor-bearing mice were given NS, Cytoxan (CTX), and TASN (9.375, 18.75, and 37.5 mg/kg) by sc, respectively. SA content and blocking degree of tumor cell membrane in H_(22) mice were determined by chromatometry. Results TASN could decrease the SA content and the blocking degree of tumor cell membrane in H_(22) tumor-bearing mice in a dose-dependent manner. Conclusion TASN shows the antitumor activity through decreasing the SA content and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice. |
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| Keywords: | total alkaloid of Solanum nigrum L (TASN) H_(22) tumor-bearing mice blocking degree of membrane sialic acid (SA) |
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