氟砷染毒对大鼠生殖发育毒性的研究

为探讨氟砷染毒对生殖功能和子代发育的影响，采用两代一窝繁殖实验的方法，观察Ｗｉｓｔａｒ大鼠暴露于氟（ＮａＦ）砷（Ａｓ２Ｏ３）后其生殖功能和子代生长发育的变化，以及卵巢的病理改变。结果表明，随着染毒剂量的增加，受孕率、正常分娩率、出生存活率和哺育成活率随之降低；如高剂量组受孕率Ｆ０和Ｆ１代分别为７３．０８％和６１．５４％，而对照组为９２．３１％和８４．６２％；而体氟和体砷显著增加；高剂量组子代体重明

Toxic effect of fluoride-arsenic on the reproduction and development of rats

To determine the effects of the fluoride arsenic exposure on the reproductive function and the development of offspring. Two generations one nest reproduction was studied in Wistar rats to assess the changes of reproductive function and structure of ovary and development of their offspring after rats were exposed to different doses of fluoride(NaF) arsenic(As 2O 3)orally. The rates of the pregnancy, normal parturition, survival and feeding survival in high dose group were lower than that in low dose groups and control. The rates of pregnancy were 73 08% and 61 54% in high dose groups, and 92 31% and 84 62% in the control. But the contents of fluoride and arsenic in rats' offspring were increased. The weights of rats' offspring in high dose group were lighter than that in control, The average weights were 38 45g in high dose group and 60 84g in control one month after birth. Pathological changes could be found in each stage of oocytes with transmission electron microscope(TEM). Conclusion\ Fluoride arsenic exposure has adverse effects on the reproductive system and the development of rats' offspring.