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| 头孢吡肟中间体合成条件考察 | |
| 引用本文： | 包立道,多丽霞,秦荣.头孢吡肟中间体合成条件考察[J].内蒙古医学院学报,2004,26(2):105-107. |
| 作者姓名： | 包立道 多丽霞 秦荣 |
| 作者单位： | 1. 内蒙古医学院,药学系,内蒙古,呼和浩特,010059 2. 嘉事堂药业北京医药生物新技术分公司 3. 内蒙古医学院第一附属医院 |
| 摘 要： | 目的：在现有的实验室务件下以7-ACA为原料合成头孢吡肟中间体，并在一定程度上提高收率。方法：与国外文献报道的相关方法具有一致性，同时，采用正交实验设计方法考察了一些关键步骤(时间、温度、剂量)对中间体收率的影响。结果：中间体收率为32．7％。结论：该方法使中间体的合成更易于控制，避免了一些繁杂的操作，并降低了实验成本。 |
| 关 键 词： | 头孢吡肟 中间体 正交设计 三甲基碘硅烷 |
| 文章编号： | 1004-2113(2004)02-0105-03 |
| 修稿时间： | 2003年11月25 |
THE INVESTIGATION OF THE SYNTHESIS OF THE KEY INTERMEDIATE OF CEFEPIME DIHYDROCHLORIDE |
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| BAO Li-dao,DUO Li-xia,Qin Rong.THE INVESTIGATION OF THE SYNTHESIS OF THE KEY INTERMEDIATE OF CEFEPIME DIHYDROCHLORIDE[J].Acta Academiae Medicinae Neimongol,2004,26(2):105-107. | |
| Authors: | BAO Li-dao DUO Li-xia Qin Rong |
| Abstract: | Objective: In current laboratorial condition, using 7-ACA to synthesize 7-amino-3-(1-methyl-1-pyrrolidine)methyl]-3-cephem-4-carboxylic acid hydrochloride which is the key intermediate of the synthesis of cefepime dihydrochloride, and increase the yield. Methods: This method is consistent with the methods which have been reported on foreign literature, and this orthogonal experimental design has investigated some key step (time, temperature, dosage). Results: The average yield was 32.7%. Conclusion: The new method has advantages such as convenient operation and high yield, avoids some miscellaneous operations, found the best way to synthesize the intermediate. |
| Keywords: | cefepime intermediate orthogonal experimental design TMSI |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |