Intensity of synthesis of phospholipids and cholesterol in the brain and spinal cord of rabbits with experimental allergic encephalomyelitis

Experimental allergic encephalomyelitis (EAE) was induced in rabbits by inoculation of homologous spinal cord myelin. In the terminal state of the disease acetate-2-C¹⁴ was injected in a dose of 50 Ci/100 g body weight and the animals were killed 2 h later. The intensity of synthesis of phospholipids and cholesterol was greatly reduced in EAE not only in the lumbar region of the spinal cord, where the injury to myelin was greatest, but also in the brain stem, where demyelinization was absent.Department of Biochemistry, I. P. Pavlov First Leningrad Medical Institute. Laboratory of Pathology of the Nervous System, Research Institute of Éxperimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR V. S. Il'in.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 291–293, March, 1976.